BTK, Bruton tyrosine kinase, 695

N. diseases: 290; N. variants: 85
Disease: Autoimmune disease (systemic) NOS ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2895206
Disease: Autoimmune disease (systemic) NOS
Autoimmune disease (systemic) NOS 		0.030 Biomarker disease BEFREE Although BCR-TLR interplay is complex, our findings show that both signaling pathways are crucial for the development of pathology in a Btk-dependent model for systemic autoimmune disease. 30761150 2019
CUI: C2895206
Disease: Autoimmune disease (systemic) NOS
Autoimmune disease (systemic) NOS 		0.030 AlteredExpression disease BEFREE Interestingly, increased BTK protein expression in patients with systemic autoimmune disease appears to be correlated with autoantibody production. 29717662 2018
CUI: C2895206
Disease: Autoimmune disease (systemic) NOS
Autoimmune disease (systemic) NOS 		0.030 Biomarker disease BEFREE Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease. 26341110 2016