|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), activating mutations of NOTCH1 are observed in more than 50% of cases, whereas the t(7;9)(q34;q34) involving NOTCH1 at 9q34 and TRB@ at 7q34 is an extremely rare but recurrent translocation.
|
23033986 |
2013 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of a t(7;19)(q34;p13) in a pediatric T-cell acute lymphoblastic leukemia patient led to the identification of a translocation between the TRB@ and LYL1 loci.
|
22058201 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus.
|
15774621 |
2005 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Dominant Variable (V) and Joining (J) gene pair rearrangements in cancer cells were confirmed by polymerase chain reaction (PCR) amplification and Sanger sequencing; clonality assessment of clinical isolates using BIOMED-2 methods showed agreement for 73% and 77% of samples at the β and γ loci, respectively, whereas β locus V and J allele prevalence in PBMCs were well correlated with results from commercial PCR-based DNA sequencing assays (<i>r</i><sup>2</sup> = 0.94 with Adaptive ImmunoSEQ, 0.77-0.83 with Invivoscribe LymphoTrack TRB Assay).
|
30530777 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients.
|
29632706 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
However, because T-cell malignancies contain identically rearranged T-cell receptor gamma (TCRG) and/or beta (TCRB) genes, the polymerase chain reaction (PCR) can be a fast, convenient, and dependable option to identify clonal T-cell processes.
|
23666697 |
2013 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
High frequencies of TRGV-BJ hybrid gene (rearrangement between the TRB and TRG loci at 7q35 and 7p14-15, respectively) have been detected in lymphocytes from patients with ataxia telangiectasia (AT), and also in patients with lymphoid malignancies.
|
19142737 |
2009 |
|
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Validation of BIOMED-2 multiplex PCR tubes for detection of TCRB gene rearrangements in T-cell malignancies.
|
15284865 |
2004 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
TCRB gene rearrangement patterns differed between the various categories of T cell malignancies.
|
10360387 |
1999 |
|
Mycosis Fungoides
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Pre- and posttreatment biopsies from 20 lesional skin samples of 18 patients with mycosis fungoides who received either 8 Gy LDRT (<i>n</i> = 16) or topical steroids (<i>n</i> = 4) underwent high-throughput T-cell receptor sequencing of the TCRB gene to quantify the malignant T-cell clone.
|
31636100 |
2020 |
|
Mycosis Fungoides
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Gains of TCRB and TCRG genes were observed in 23% (3 of 13) of SS and 50% (3 of 6) of MFt, reflecting the presence of trisomy and/or tetrasomy of chromosome 7 already detected by conventional cytogenetics and array comparative genetic hybridization techniques.
|
21872828 |
2011 |
|
Mycosis Fungoides
|
0.050 |
Biomarker
|
group |
BEFREE |
There is limited information regarding the performance characteristics and utility of TCRG and TCRB clonality assays in diagnosis of MF and ID from paraffin-embedded tissue sections.
|
20203005 |
2010 |
|
Mycosis Fungoides
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
LHGDN |
Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements.
|
12594835 |
2003 |
|
Mycosis Fungoides
|
0.050 |
Biomarker
|
group |
BEFREE |
Lymph node TCRB gene analysis provides additional prognostic information for patients with mycosis fungoides with intermediate LN histopathology.
|
9487207 |
1998 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar.
|
9409647 |
1997 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
|
9336413 |
1997 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Ten TCRB allelic polymorphisms were analyzed from 3 groups of white women: 112 with RA, 72 with systemic lupus erythematosus, and 70 healthy controls.All participants were also HLA typed.
|
8651986 |
1996 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results argue against the hypothesis that TCRB polymorphisms play a crucial role in the susceptibility for RA.
|
7979596 |
1994 |
|
Neoplasm, Residual
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
As expected, HTS of TCRB and TCRG identified MRD that was not detected by flow cytometry in a subset of cases (25 of 35 HTS compared with 13 of 35, respectively), which highlights the potential of this technology to define lower detection thresholds for MRD that could affect clinical treatment decisions.
|
22593176 |
2012 |
|
Neoplasm, Residual
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, TCRB gene rearrangements occur in 35% of precursor-B-ALL patients and are relatively stable and sensitive PCR targets for detection of minimal residual disease, particularly if this concerns complete Vbeta-(Dbeta)-Jbeta rearrangements.
|
15470492 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM.
|
10075863 |
1999 |
|
Neoplasm, Residual
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The occurrence of the different types of TCRB rearrangement patterns has implications for PCR-based clonality assessment and for PCR-based detection of minimal residual disease via TCRB gene analysis.
|
10360387 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas.
|
8909943 |
1996 |