leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several means of analyzing minimal residual disease (MRD) in leukemia involving the rearranged T cell receptor (TCR) gene have been described.
|
9111164 |
1997 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sought to address the question of clonal variation of TCR within a human T leukemia cell line, HPB-ALL.
|
3262674 |
1988 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since this patient represents a de novo acute leukemia as evaluated by location of the translocation-breakpoint on chromosome 22, our data clearly indicate that Ig- and TCR gene rearrangements might prove a valuable addition in monitoring Ph1+ hybrid leukemias, providing guidelines for optimizing chemotherapy.
|
1312481 |
1992 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Utilizing newborn screening ('Guthrie') cards, leukemic clones have been detected retrospectively in dried blood spots using two different PCR-based approaches: (i) the amplification of patient/leukemia-specific breakpoint fusion sequences of rearranged oncogenes; and (ii) the amplification of clonal immunoglobulin heavy chain gene (IgH) or T cell receptor (TcR) gene rearrangements.
|
15061193 |
2004 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although quantitative detection of clonal immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements is currently considered to be the standard method, leukaemia fusion genes provide other possible targets for MRD follow-up, as already demonstrated in TEL/AML1-positive ALLs.
|
19158828 |
2009 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heteroduplex analysis with standardized DHPLC conditions simplifies the detection of unknown clonal or polyclonal TCR rearrangements in newly diagnosed leukemias.
|
11673369 |
2001 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analysed 49 children with acute leukaemia (29 B-precursor acute lymphoblastic leukaemia (ALL), 5 relapsed cALL, 6 T-ALL, 7 acute non-lymphocytic (ANLL) and 2 mixed lineage leukaemias), for the presence of different immune system gene rearrangements (Ig JH, C kappa, C lambda, TCR J gamma, C beta, J delta and J alpha) by Southern blot hybridisation.
|
7786608 |
1995 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR delta gene recombination patterns were analysed by Southern blot, polymerase chain reaction and nucleotide sequencing in acute myeloid leukaemias, with coexpression of lymphoid antigens (Ly+ AML, n=10) as well as in early T-cell acute lymphoblastic leukaemias with (My+ T-ALL, n=10) and without coexpression of myeloid antigens (My(-) T-ALL, n=9).
|
8616087 |
1996 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, despite their putative "B-cell precursor" lineage, these leukemias manifest a remarkably high incidence of TCR gene rearrangements.
|
2307988 |
1990 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development.
|
25388957 |
2015 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a correlation between T-cell receptor (TCR) gene rearrangements and chromosomal aberrations has been implicated in this leukemia.
|
7510355 |
1994 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of previous analyses of T-cell receptor (TCR) gene rearrangement patterns, we hypothesized that some late recurrences of T-ALL might in fact represent second leukemias.
|
21357790 |
2011 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pattern of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements was determined in 87 patients with acute and chronic leukaemias and myelodysplastic syndromes by Southern blot hybridisation.
|
1850943 |
1991 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 3 of 15 patients, the leukemia and histiocytic lesion shared immunoglobulin H or monoclonal TCR gene rearrangements and, in 4 of 15 patients, clonal identity was documented by fluorescence in situ hybridization.
|
19642834 |
2010 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern analysis and polymerase chain reaction (PCR) were used to detect the rearranged V-D-J segment of T-cell receptor delta (TCR delta) gene from malignant cell specimens of patients with leukemia and lymphoma of T-cell lineage.
|
8756082 |
1996 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL.
|
3025859 |
1987 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A previously established human leukemia cell line, designated THP-6, was further characterized with respect to cell surface antigen expression and immunoglobulin(Ig) and T-cell receptor(TCR) gene status.
|
3130528 |
1988 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that monoclonal proliferation of TCR gamma delta-positive granular lymphocytes (GL) can be associated with PRCA even in a patient having a small proportion of leukemia GL, which we propose to designate as 'smoldering GLL'.
|
7653209 |
1995 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order better to characterize this type of leukaemia, we have investigated the immunoglobulin (Ig) and T-cell receptor (TCR) genes configuration of 21 infants with ALL, and compared the genotypic features with the phenotypic and karyotypic data, as well as with the clinical outcome.
|
1316141 |
1992 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern analysis and polymerase chain reaction (PCR) were used to detect the rearranged V-D-J segment of T-cell receptor delta (TCR delta) gene from malignant cell specimens of patients with leukemia and lymphoma of T-cell lineage.
|
9209365 |
1997 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukaemia is a monoclonal disease which frequently displays clonal rearrangement of the T-cell receptor gamma (TCR gamma) and/or immunoglobulin heavy chain (IgH) gene.
|
9507369 |
1997 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings clearly limit the use of HMMR-TCR therapy to MHC- mismatched HSC transplantation, in which HLA-A2 differences can be used to restrict recognition to patient HSCs and leukemia.
|
22371883 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four of five TCR tau delta+ leukemias carried rearrangements of the C tau 2 gene, and transcribed the T-early alpha genetic element.
|
1826854 |
1991 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of these PCR assays was based on amplification of leukemia-specific TCR-delta gene rearrangements, while the other assay relied upon detection of the c-tal deletion.
|
8182934 |
1994 |