|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia.
|
12393705 |
2003 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukemia fusion gene analysis demonstrated positive EVI1 and negative IgH and TCR gene rearrangement.
|
30608452 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukaemia is a monoclonal disease which frequently displays clonal rearrangement of the T-cell receptor gamma (TCR gamma) and/or immunoglobulin heavy chain (IgH) gene.
|
9507369 |
1997 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCR-Vbeta flow cytometric analysis of peripheral blood for assessing clonality and disease burden in patients with T cell large granular lymphocyte leukaemia.
|
20154036 |
2010 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TCR-beta chain gene rearrangement and expression in human T-cell development and in leukemia.
|
8207984 |
1994 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR delta gene recombination patterns were analysed by Southern blot, polymerase chain reaction and nucleotide sequencing in acute myeloid leukaemias, with coexpression of lymphoid antigens (Ly+ AML, n=10) as well as in early T-cell acute lymphoblastic leukaemias with (My+ T-ALL, n=10) and without coexpression of myeloid antigens (My(-) T-ALL, n=9).
|
8616087 |
1996 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A previously established human leukemia cell line, designated THP-6, was further characterized with respect to cell surface antigen expression and immunoglobulin(Ig) and T-cell receptor(TCR) gene status.
|
3130528 |
1988 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although quantitative detection of clonal immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements is currently considered to be the standard method, leukaemia fusion genes provide other possible targets for MRD follow-up, as already demonstrated in TEL/AML1-positive ALLs.
|
19158828 |
2009 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of a clonal T cell receptor (TCR) gene rearrangement is used in the diagnosis of primary cutaneous T cell lymphomas (CTCL) whereas chromosomal aberrations serve as a diagnostic tool for leukaemias and nodal lymphomas.
|
15086537 |
2004 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four of five TCR tau delta+ leukemias carried rearrangements of the C tau 2 gene, and transcribed the T-early alpha genetic element.
|
1826854 |
1991 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heteroduplex analysis with standardized DHPLC conditions simplifies the detection of unknown clonal or polyclonal TCR rearrangements in newly diagnosed leukemias.
|
11673369 |
2001 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterogeneous TCR delta Vdelta2-Ddelta3 rearrangements and their relation to IgH and TCR gamma gene status in childhood B cell precursor leukaemias.
|
10613353 |
1999 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 3 of 15 patients, the leukemia and histiocytic lesion shared immunoglobulin H or monoclonal TCR gene rearrangements and, in 4 of 15 patients, clonal identity was documented by fluorescence in situ hybridization.
|
19642834 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, PCR amplification of segments of rearranged TCR-beta is reliable and highly suitable for the detection of small populations of clonal T-cells in asymptomatic HTLV-I carriers who present abnormal peripheral blood lymphocytes providing an additional instrument for following up these patients with potentially higher risk of leukemia.
|
15917950 |
2005 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order better to characterize this type of leukaemia, we have investigated the immunoglobulin (Ig) and T-cell receptor (TCR) genes configuration of 21 infants with ALL, and compared the genotypic features with the phenotypic and karyotypic data, as well as with the clinical outcome.
|
1316141 |
1992 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analysed 49 children with acute leukaemia (29 B-precursor acute lymphoblastic leukaemia (ALL), 5 relapsed cALL, 6 T-ALL, 7 acute non-lymphocytic (ANLL) and 2 mixed lineage leukaemias), for the presence of different immune system gene rearrangements (Ig JH, C kappa, C lambda, TCR J gamma, C beta, J delta and J alpha) by Southern blot hybridisation.
|
7786608 |
1995 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3 delta is not detectably expressed at the mRNA or protein level in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described.
|
3118113 |
1987 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neither TCR gene was found to be rearranged in acute nonlymphoid leukemia patients (0/12) or in patients with B-cell (surface immunoglobulin-positive) leukemia (0/3).
|
2955409 |
1987 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of previous analyses of T-cell receptor (TCR) gene rearrangement patterns, we hypothesized that some late recurrences of T-ALL might in fact represent second leukemias.
|
21357790 |
2011 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One is based on the detection of aberrant expression of leukemia specific antigens by flow cytometry and the other one uses the specific rearrangements of the TCR or Ig genes, which can be detected by quantitative PCR in the DNA of leukemic cells.
|
23233572 |
2012 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of these PCR assays was based on amplification of leukemia-specific TCR-delta gene rearrangements, while the other assay relied upon detection of the c-tal deletion.
|
8182934 |
1994 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development.
|
25388957 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL.
|
3025859 |
1987 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings clearly limit the use of HMMR-TCR therapy to MHC- mismatched HSC transplantation, in which HLA-A2 differences can be used to restrict recognition to patient HSCs and leukemia.
|
22371883 |
2012 |