TDO2, tryptophan 2,3-dioxygenase, 6999

N. diseases: 89; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931837
Disease: Familial hypertryptophanemia
Familial hypertryptophanemia 		0.510 GeneticVariation disease UNIPROT Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. 28285122 2017
CUI: C2931837
Disease: Familial hypertryptophanemia
Familial hypertryptophanemia 		0.510 GeneticVariation disease BEFREE Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. 28285122 2017
CUI: C2931837
Disease: Familial hypertryptophanemia
Familial hypertryptophanemia 		0.510 GermlineCausalMutation disease ORPHANET Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. 28285122 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom. 30519155 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom. 30519155 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population. 24376086 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population. 26057341 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population. 24376086 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population. 26057341 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. 24196946 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. 24196946 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. 23336047 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 23467366 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. 23336047 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 23467366 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. 17692928 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. 17692928 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease BEFREE Compared to the control group, the HPLC, RT-PCR, and immunohistochemistry results show significant elevation of (1) kynurenine in schizophrenia (1.9-fold, P = 0.02), and in bipolar disorder (1.8-fold, P = 0.04), primarily in the bipolar subgroup with psychosis (2.1-fold, P = 0.03); (2) TDO2 mRNA in schizophrenia (1.7-fold; P = 0.049); and (3) the immunohistochemistry values for the density of TDO2-positive white matter glial cells in schizophrenia (P = 0.01) and in major depression (P = 0.03) as well as the density and intensity of glial cells (in both gray and white matter) stained for TDO2 in bipolar disorder (P = 0.02). 16448631 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease BEFREE Compared to the control group, the HPLC, RT-PCR, and immunohistochemistry results show significant elevation of (1) kynurenine in schizophrenia (1.9-fold, P = 0.02), and in bipolar disorder (1.8-fold, P = 0.04), primarily in the bipolar subgroup with psychosis (2.1-fold, P = 0.03); (2) TDO2 mRNA in schizophrenia (1.7-fold; P = 0.049); and (3) the immunohistochemistry values for the density of TDO2-positive white matter glial cells in schizophrenia (P = 0.01) and in major depression (P = 0.03) as well as the density and intensity of glial cells (in both gray and white matter) stained for TDO2 in bipolar disorder (P = 0.02). 16448631 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE TDO2[CC]+MC5R[G, any]+MCHR2[GC] conferred an OR maximal for schizophrenia alone (4.84, p=0.005), carried by 8% of schizophrenia cases. 19502010 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE Compared to the control group, the HPLC, RT-PCR, and immunohistochemistry results show significant elevation of (1) kynurenine in schizophrenia (1.9-fold, P = 0.02), and in bipolar disorder (1.8-fold, P = 0.04), primarily in the bipolar subgroup with psychosis (2.1-fold, P = 0.03); (2) TDO2 mRNA in schizophrenia (1.7-fold; P = 0.049); and (3) the immunohistochemistry values for the density of TDO2-positive white matter glial cells in schizophrenia (P = 0.01) and in major depression (P = 0.03) as well as the density and intensity of glial cells (in both gray and white matter) stained for TDO2 in bipolar disorder (P = 0.02). 16448631 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET Unlike the results for schizophrenia and bipolar disorder, the increase in TDO2 protein in the major depression group was not associated with an increase in kynurenine concentration. 16448631 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population. 25152196 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. 24196946 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. 21396719 2011