TDO2, tryptophan 2,3-dioxygenase, 6999

N. diseases: 89; N. variants: 1
Disease: Mental Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 Biomarker disease BEFREE Before its link to cancer immunotherapy was discovered in 2011, the search for TDO2 inhibitors was initially driven by depression therapy. 30526149 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 Biomarker disease BEFREE Finally, this review is also directed toward assessing whether IDO and TDO are potential therapeutic target in depression associated with other diseases such as diabetes and/or cancer, as well as the development of potent IDO and TDO inhibitors. 30014175 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 AlteredExpression disease BEFREE A dysfunction of the tryptophan catabolites pathway, indicated by increased levels of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase, is also involved in the development of depression. 28951145 2018