TDO2, tryptophan 2,3-dioxygenase, 6999

N. diseases: 89; N. variants: 1
Disease: Triple Negative Breast Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.030 AlteredExpression disease BEFREE To identify mechanism(s) that permit TNBC to express TDO2 and other proteins not expressed in the more well-differentiated ER<sup>+</sup> breast cancers, miRNA-200c was restored in TNBC cell lines. 30213797 2019
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.030 Biomarker disease BEFREE Furthermore, it is demonstrated that anchorage-independent TNBC utilizes the tryptophan-catabolizing enzyme tryptophan 2,3-dioxygenase (TDO) to inhibit CD8 T-cell viability. 30143553 2019
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.030 AlteredExpression disease BEFREE In clinical specimens of TNBC, elevated expression of TDO2 was associated with increased disease grade, estrogen receptor-negative status, and shorter overall survival. 26363006 2015