We found distinct tendencies in protein expression and three candidate breast cancer biomarkers (carbonic anhydrase 2, catalase, and peroxiredoxin-2) whose levels differed significantly between ND specimens from patients with and without breast cancer.
The goal of these investigations was to elucidate the antiproliferative action of PRP-1 on the breast carcinoma cell line MDA 231 (ER-) and to compare PRP-1 action previously reported on other mesenchymal tumors.
Three of five autoantibodies, FKBP52, PPIA, and PRDX2, showed significantly increased reactivity in primary breast cancer and CIS compared with healthy controls.
To identify epigenetically-regulated genes in breast cancer, MCF-7 cells were exposed to 250 nM 5-aza or 5-aza + 50 nM TSA for three weeks followed by a five week recovery period after treatment withdrawal and gene expression patterns were examined by microarray analysis.