|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
A novel TERT variant, A243V, was identified in a 65-year-old male with advanced HCC and cirrhosis secondary to chronic hepatitis C virus (HCV) and alcohol ingestion, but direct assay measurements in vitro did not detect modulation of telomerase enzymatic activity or processivity.
|
28813500 |
2017 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Here we determine a potential association of CHB/LC with the genetic variant of telomerase reverse transcriptase (TERT), a key player in aging including immune-senescence.
|
28300824 |
2017 |
|
Liver Cirrhosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Serum miRNA155 levels and blood and tissue hTERT mRNA were detected by real-time quantitative reverse-transcriptase PCR (RT-qPCR) among liver cirrhosis and HCC patients.
|
27751368 |
2016 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Several lines of evidence suggest that this process is involved in liver disease progression: (a) telomere shortening and alterations in the expression of proteins protecting the telomere are associated with cirrhosis and hepatocellular carcinoma; (b) advanced liver damage is a feature of a spectrum of genetic diseases impairing telomere function, and inactivating germline mutations in the telomerase complex (including human Telomerase Reverse Transcriptase (hTERT) and human Telomerase RNA Component (hTERC)) are enriched in cirrhotic patients independently of the etiology; and (c) experimental models suggest that telomerase protects from liver fibrosis progression.
|
26999107 |
2016 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis.
|
25123086 |
2014 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TERT, the catalytic component, and TERC, the RNA template, can behave as risk factors for the development of bone marrow failure, pulmonary fibrosis, and hepatic cirrhosis.
|
22507770 |
2012 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The telomerase RNA component (TERC) and the telomerase reverse transcriptase (TERT) were sequenced in 1,121 individuals (521 patients with cirrhosis induced by chronic liver disease and 600 noncirrhosis controls).
|
21520174 |
2011 |
|
Liver Cirrhosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The allele frequency for the most common missense TERT variant was significantly higher in patients with cirrhosis (2.6%) than in 2,000 controls (0.7%; P = 0.0011).
|
21520173 |
2011 |
|
Liver Cirrhosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We performed RT-PCR to detect the expression of hTERT mRNA in 78 patients with HCC, 10 with liver cirrhosis (LC), 12 with chronic hepatitis (CH), and 34 healthy individuals without any liver diseases and cancers, and statistically analyzed the association with clinical parameters which include age, sex, etiology, Child classification, underlying liver disease, biochemical data, alpha-fetoprotein (alpha-AFP) number and size of tumor, and histological differentiation of HCC regarding HCC patients.
|
12759542 |
2003 |