Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we present a novel genome-wide candidate SNP for PDAC risk (TERT-rs2736100), a completely new signal (NAF1-rs7675998) approaching genome-wide significance and we report a strong association between the teloscore and risk of pancreatic cancer, suggesting that telomeres are a potential risk factor for pancreatic cancer.
|
30325019 |
2019 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer.
|
29019414 |
2017 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
|
25284078 |
2015 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed an in-depth analysis of genetic variability of the telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC) genes, in 5,550 subjects with pancreatic cancer and 7,585 controls from the PANcreatic Disease ReseArch (PANDoRA) and the PanScan consortia.
|
25940397 |
2015 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The COOH-terminal half fragment of CPE (C-CPE) enhances the effectiveness of clinically relevant chemotherapies and can be used as a carrier for drugs and other bacterial toxins to claudin-4-positive cancer cells. hTERT-HPDE cells, in which the human telomerase reverse transcriptase (hTERT) gene is introduced into normal HPDE cells, may be a useful model of normal HPDE cells not only for physiological regulation of claudin-4 expression but also for developing safer and more effective therapeutic methods targeting claudin-4 in pancreatic cancer.
|
22800288 |
2012 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk.
|
22125638 |
2011 |
Pancreatic carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Positive regulation of human telomerase reverse transcriptase gene expression and telomerase activity by DNA methylation in pancreatic cancer.
|
19194757 |
2009 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quantitative analysis of human telomerase reverse transcriptase in pancreatic cancer.
|
16609017 |
2006 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer.
|
15788678 |
2005 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To clarify growth inhibition in pancreatic cancer cells by interference with the hTR component of the telomerase reverse transcriptase enzymatic complex.
|
12215291 |
2002 |