TFAP2A, transcription factor AP-2 alpha, 7020

N. diseases: 250; N. variants: 20
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). 27663566 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE This circuitry, besides confirming the central role of AP2α in orchestrating melanoma development and/or progression, further displays the significance of these miRs in cancer and the option of utilizing them for novel therapeutics. 26434590 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Based on our data, we conclude that TFAP2A expression in human melanomas can be silenced by aberrant CpG methylation of the TFAP2A promoter. 25625848 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE The new HIF2α partners microphthalmia-associated transcription factor, SOX10, and AP2α, which are master actors of melanoma development, were confirmed via co-immunoprecipitation experiments. 23275444 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Our recent data indicate that CREB/ATF-1 regulates the expression of AP-2α, thus, supporting the notion that CREB is an important "master switch" in melanoma progression. 21147226 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Since AP-2alpha regulates several genes associated with the metastatic potential of melanoma including c-KIT, VEGF, PAR-1, MCAM/MUC18, and p21(Waf1), our data identified CREB as a major regulator of the malignant melanoma phenotype. 20805990 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN Previously, we demonstrated that loss of the activator protein-2alpha (AP-2alpha) expression results in overexpression of the protease-activated receptor-1 (PAR-1) in human melanoma cell lines. 16946713 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE An activator protein-2, which has a tumor suppressor-like role in melanoma, increased skeletrophin expression. 16715130 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE These findings suggest that the loss of AP-2alpha protein expression during the progression of melanoma could be related to mutation of the gene in only a small number of tumours, whereas the expression and activation of caspases, most prominently caspase-6, may be an important factor for the down-regulation of AP-2alpha protein. 14517845 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2alpha in cutaneous melanoma. 10864211 2000