|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, elevated miR-143 or exosome-miR-143 or silencing TFF3 inhibited the expression of TFF3, proliferating cell nuclear antigen (PCNA), matrix metalloproteinase (MMP)-2, and MMP-9 and PC3 cell proliferation, migration, invasion, and tumor growth, whereas it promoted apoptosis.
|
31563120 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trefoil factor family peptide 3 (TFF3) is supposed to have tumor suppressive functions in retinoblastoma (RB), but the functional pathway is not completely understood.
|
31450568 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis.
|
30519349 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The highly specific expression of TFF3 in MBOT may help to further clarify potential relationships of tumors with mucinous histology and warrants further studies.
|
28470574 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TFF3-silenced cells showed suppressed tumor cell growth and migration.
|
30139961 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemically, TFF1 expression was positive in 56.5% and TFF3 was positive in 73.9% of breast cancers, while TFF2 was negative in all tumors.
|
28687783 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, high serum trefoil factor 3 levels were associated with poor tumor differentiation and clinical TNM stage ( P < .05).
|
27760866 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage.
|
28405143 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There were significantly higher rates of TFF3 positivity in patients with deep invasive tumors and advanced stage ones.
|
25514872 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TFF3 protein expression was positively associated with larger tumour size, lymph node metastasis, higher stage, and poor survival outcome.
|
25266665 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FNA and tumor expression of human telomerase reverse transcriptase (hTERT), high-mobility group A2 (HMGA2), and trefoil factor 3/3-galactoside-binding lectin (T/G ratio) were analyzed.
|
24713092 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Multivariate analysis demonstrated Her-2/neu and TFF3 to be independent prognostic indicators of recurrence, and a significantly poor prognosis for expression of TFF3 in patients with Her-2/neu negative tumors.
|
23822993 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, forced expression of TFF3 increased tumor size in xenograft models.
|
21170268 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This finding, along with the fact that ITF-2B is a regulator of the key cell cycle inhibitor p21(Cip1), indicates that ITF-2B is a tumor suppressor that has an important function at the adenoma to carcinoma transition.
|
19394332 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Development of TFF3-based diagnostic methods is now ongoing and it may not be long before thyroid follicular carcinoma can be diagnosed preoperatively using an aspirated sample from the tumor.
|
18506086 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TNF-alpha stimulation evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29.
|
12912861 |
2003 |