|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next, we investigated the role of TfR1 in the development of diabetic kidney disease.
|
31838906 |
2020 |
|
Paroxysmal nocturnal hemoglobinuria
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have added allophycocyanin (APC)-conjugated CD71 to the existing CD235aFITC/CD59PE RBC assay allowing simultaneous delineation and quantification of PNH Type III and Type II immature RBCs (iRBCs).
|
31705743 |
2020 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Primarily, to ascertain an association of TfR1 in the pathophysiology of renal fibrosis, we induced unilateral ureteral obstruction in wild-type (WT) and heterozygous TfR1 deleted (<i>TfR1</i><sup>+/-</sup>) mice.
|
31838906 |
2020 |
|
Zinc deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
In children with anaemia, rates of iron deficiency (low ferritin based on inflammation status, and/or high soluble transferrin receptor, ≥1.97 mg/L) and zinc deficiency (serum zinc <65 μg/dl) were 81.1% and 53.7%, respectively.
|
31595712 |
2020 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer.
|
30651591 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Primary outcomes were markers of iron status (serum ferritin, hemoglobin, soluble transferrin receptor, total body iron stores) and secondary outcomes were self-reported fatigue and energy.
|
29533710 |
2019 |
|
Gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of Phosphoglucosamine mutase (glmM), cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA) genes and mRNA expression of Iron Regulatory Protein 2 (IRP2), Transferrin Receptor (TFRC) and Ferritin Light Chain (FTL) genes in samples of 28 normal gastric mucosa, 33 chronic gastritis, 29 gastritis with intestinal metaplasia, 29 intestinal type adenocarcinoma patients were examined by real-time PCR.
|
30391537 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reduced frequency and/or impaired functionality of CD71+ erythroid cells during pregnancy may predispose IBD patients to a more pro-inflammatory milieu in their gastrointestinal tract, characterised by lower Tregs, higher IL-6, and TNF-α, and dysbiosis.
|
30272151 |
2019 |
|
Lung diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Conclusions:</b> Taken together, these data highlight how CD71 delineates AM subsets that play distinct roles in IPF and furthermore show that CD71<sup>-</sup> AMs may be an important pathogenic component of fibrotic lung disease.
|
31051082 |
2019 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TfR1 and VEGF are potential prognostic factors for osteosarcoma.
|
31484533 |
2019 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We then employed transferrin receptor 1 (TFR1) targeting liposomes to codeliver DFO and YC1 to pancreatic tumors in a mouse model.
|
30676731 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways.
|
30552136 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that sIgA may promote human lung inflammation and fibrosis by enhancing production of inflammatory or fibrogenic cytokines as well as extracellular matrix, inducing fibroblast differentiation into myofibroblasts and promoting human lung fibroblast proliferation. sIgA's enhancement of cytokine production may be due partially to its binding to CD71 or the secretory component.
|
30570135 |
2019 |
|
Reoviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Transferrin Receptor 1-Associated Iron Accumulation and Oxidative Stress Provides a Way for Grass Carp to Fight against Reovirus Infection.
|
31766619 |
2019 |
|
Restless Legs Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RLS compared with Control participants showed higher levels of nEV total ferritin but similar levels of transferrin receptor and ferroportin.
|
30895312 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Our analysis revealed that several markers could be useful for sepsis diagnosis, such as CD45RA, CD45RO, or CD71 on T cells; HLA-DR on NKT or classic monocytes, and TREM-1 on non-classic monocytes or neutrophils.
|
31537145 |
2019 |
|
Vitamin A Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
From a cohort of children (n = 820), 4-8 years of age participating in a randomized controlled trial of pro-vitamin A, we estimated attributable fractions for anemia (hemoglobin of <110 or 115 g/L, by age) owing to current malaria or inflammation (C-reactive protein of >5 mg/L, or α-1 acid glycoprotein of >1 g/L, or both), and current or prior iron deficiency (ID; defined as low ferritin [<12 or 15 μg/L for age <5 or >5 years] or functional ID [soluble transferrin receptor of >8.3 mg/L] or both) and vitamin A deficiency (retinol of <0.7 μmol/L), during low and high malaria seasons, using multivariate logistic regression.
|
31402145 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
We selected the more promising candidate (H7), based on its ability to inhibit TfR1-mediated iron-loaded transferrin internalization in Raji cells (B-cell lymphoma).
|
30604643 |
2019 |
|
Chronic gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of Phosphoglucosamine mutase (glmM), cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA) genes and mRNA expression of Iron Regulatory Protein 2 (IRP2), Transferrin Receptor (TFRC) and Ferritin Light Chain (FTL) genes in samples of 28 normal gastric mucosa, 33 chronic gastritis, 29 gastritis with intestinal metaplasia, 29 intestinal type adenocarcinoma patients were examined by real-time PCR.
|
30391537 |
2019 |
|
Alcohol abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of TFR-1 in HCC was associated with the absence of alcohol abuse (P = 0.0467), liver cirrhosis (P < 0.0001), higher alpha-fetoprotein (AFP; P < 0.0001), smaller tumour size (P = 0.0022), poor histological differentiation (P < 0.0001) and morphological features (P < 0.0001).
|
30811632 |
2019 |
|
Malnutrition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using data from 1283 children in the MAL-ED (Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health) birth cohort we evaluated the risk of anemia, low retinol, zinc, and ferritin, and high transferrin receptor (TfR) at 15 mo.
|
31565748 |
2019 |
|
Erythropoietic Protoporphyria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria.
|
30712775 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Our analysis revealed that several markers could be useful for sepsis diagnosis, such as CD45RA, CD45RO, or CD71 on T cells; HLA-DR on NKT or classic monocytes, and TREM-1 on non-classic monocytes or neutrophils.
|
31537145 |
2019 |
|
Zika Virus Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Consistent with this, ZIKV infection upregulated miR-124-3p and downregulated TFRC mRNA in ZIKV-infected hNSCs and mouse brain tissue.
|
31216479 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer.
|
30651591 |
2019 |