|
Intestinal metaplasia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The presence of Phosphoglucosamine mutase (glmM), cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA) genes and mRNA expression of Iron Regulatory Protein 2 (IRP2), Transferrin Receptor (TFRC) and Ferritin Light Chain (FTL) genes in samples of 28 normal gastric mucosa, 33 chronic gastritis, 29 gastritis with intestinal metaplasia, 29 intestinal type adenocarcinoma patients were examined by real-time PCR.
|
30391537 |
2019 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.
|
30391537 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Overall, the beneficial suppression of effector function via the N292G mutation may be offset by the deleterious effect this mutation has on the plasma levels of the TfRMAb-EPO fusion protein, especially following SQ administration, which is the preferred route of administration in humans for chronic neurodegenerative diseases including AD.
|
31199881 |
2019 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
TfR1 and VEGF are potential prognostic factors for osteosarcoma.
|
31484533 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TfR1 expression was obviously higher in CRC tissues with well differentiation (<i>P</i>＝0.008), no lymph node metastasis (<i>P</i>＝0.002), no distant metastasis (<i>P</i>＝0.006), no vascular invasion (<i>P</i>＜0.001) and early TNM stage (<i>P</i>＝0.013).
|
31372038 |
2019 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression of cTFRC correlated with TFRC and negatively correlated with miR-107 both in BC cell lines and BC clinical samples.
|
30782157 |
2019 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, targeting TfR1 using the fully human anti-TfR1 H7 is a promising tool for the treatment of leukemia and lymphoma.
|
30604643 |
2019 |
|
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, targeting TfR1 using the fully human anti-TfR1 H7 is a promising tool for the treatment of leukemia and lymphoma.
|
30604643 |
2019 |
|
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, targeting TfR1 using the fully human anti-TfR1 H7 is a promising tool for the treatment of leukemia and lymphoma.
|
30604643 |
2019 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TfR1 and VEGF are potential prognostic factors for osteosarcoma.
|
31484533 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Thus, in CKD, decreased expression of TfR1 in erythroblasts as well as increased hepcidin levels in circulation may hamper erythroblast differentiation by decreasing the iron supply, as iron is an indispensable component of erythroblast differentiation.
|
30991414 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Measurements and Main Results:</b> There was a distinct increase in proportions of AMs lacking CD71 in patients with IPF compared with healthy control subjects.
|
31051082 |
2019 |
|
Henoch-Schonlein purpura nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these data suggested that TfR/CD71 overexpression and ERK1/2 and PI3K/AKt/mTOR activation were engaged in HMC proliferation induced by IgA1 from HSP patients, which might be related to the mesangial injury of HSPN.
|
30958627 |
2019 |
|
Limb ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Haploinsufficiency of TfR1 attenuated angiogenesis via reduction of mitochondrial complex I in LI in mice.
|
31541184 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that sIgA may promote human lung inflammation and fibrosis by enhancing production of inflammatory or fibrogenic cytokines as well as extracellular matrix, inducing fibroblast differentiation into myofibroblasts and promoting human lung fibroblast proliferation. sIgA's enhancement of cytokine production may be due partially to its binding to CD71 or the secretory component.
|
30570135 |
2019 |
|
Iron deficiency anemia in children
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine diagnostic usefulness of soluble transferrin receptor and soluble transferrin receptor/log ferritin index in iron deficiency anemia in children with inflammatory bowel disease.
|
30538074 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer.
|
30651591 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor was not significantly associated with chronic hyperglycaemia after acute pancreatitis.
|
28836100 |
2018 |
|
Azoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased transferrin and transferrin receptor levels were observed in seminal plasma from idiopathic azoospermia (IA) patients, suggesting disturbed iron metabolism in IA testes.
|
28762519 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cord plasma biomarkers of high iron status were non-significantly associated with higher risk of type 1 diabetes (ferritin OR = 1.05 [95%CI: 0.99-1.13] per 50 mg/L increase; soluble transferrin receptor: OR = 0.91 [95%CI: 0.81-1.01] per 0.5 mg/L increase).
|
29899542 |
2018 |
|
Gastroenteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We observed that TGEV infection promoted TfR1 internalization, clustering, and co-localization with TfR1 early in infection, while TfR1 expression was significantly down-regulated as TGEV infection proceeded.
|
30342530 |
2018 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
mRNA expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, hepcidin, hephaestin and transferrin receptor 1 in liver were higher in high fat, high cholesterol-containing diet (HFCD) group than in normal diet (ND) group. mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine.
|
29899851 |
2018 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor was not significantly associated with chronic hyperglycaemia after acute pancreatitis.
|
28836100 |
2018 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Endothelial transferrin receptor staining, which stains endothelia and reflects blood vessel density, was also unchanged at day 7, but was reduced at day 28, suggesting that breakdown of the BBB begins between day 7 and day 28 in the development of hypertension.
|
29500668 |
2018 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases.
|
29271190 |
2018 |