|
Pancytopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor (sTfR), a truncated extracellular form of TfR in serum, is an important marker of iron deficiency anemia (IDA) and bone marrow failure in cancer patients.
|
29271190 |
2018 |
|
Virus Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Finally, we found that the TGEV S1 protein interacts with the extracellular region of TfR1, and that pre-incubating TGEV with a protein fragment containing the extracellular region of TfR1 blocked viral infection.
|
30342530 |
2018 |
|
Gestational Diabetes
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM.
|
29762515 |
2018 |
|
Sensory denervation disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, a significant time x condition interaction, reflecting state-dependent plasticity, was found for the P90 only, the presence of pain decreasing the reduction of amplitude observed in response to deafferentation.
|
30346981 |
2018 |
|
Malignant Childhood Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
LMNB1 and TFRC could be potential biomarkers for this childhood cancer.
|
29742327 |
2018 |
|
Adenocarcinoma of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-7 expression was inversely correlated with TfR1 mRNA in human pancreatic adenocarcinoma patient samples.
|
29295890 |
2018 |
|
Early gastric cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CLE analysis of TfR1-targeted fluorescence imaging allowed distinction of neoplastic from non-neoplastic tissues (P < 0.0001), and TfR1 expression level was found to correlate with EGC differentiation degrees (P < 0.0001).
|
30056091 |
2018 |
|
Sleep Apnea, Obstructive
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin, soluble transferrin receptor and IL-6 levels in obese children and adolescents with and without type 2 diabetes mellitus/impaired glucose tolerance and their association with obstructive sleep apnea.
|
29305826 |
2018 |
|
Mood Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To understand the potential mechanisms involved in the beneficial effects of aspirin (ASA) in mood disorders, Alzheimer's (AD) and Parkinson's disease (PD), we investigated the effects of ASA on the expression of iron transport proteins transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1), and iron storage protein ferritin light chain (Ft-L) in interleukin-6 (IL-6)-treated PC-12 cells.
|
28987816 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD71 expression was significantly higher on T- ALL patients compared with B-ALL patients.
|
29875008 |
2018 |
|
Differentiated Thyroid Gland Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transferrin receptor-targeted HMSN for sorafenib delivery in refractory differentiated thyroid cancer therapy.
|
30584304 |
2018 |
|
Neurodegeneration with brain iron accumulation (NBIA)
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations suggest therapeutic strategies aimed at targeting impaired TfR1 recycling and palmitoylation in NBIA.
|
29395073 |
2018 |
|
Primary differentiated carcinoma of thyroid gland
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transferrin receptor-targeted HMSN for sorafenib delivery in refractory differentiated thyroid cancer therapy.
|
30584304 |
2018 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TfR1 levels in RCC tumors, particularly ccRCC, were significantly associated with adverse clinical prognostic features (anemia, lower body mass index, smoking), worse tumor pathology (size, stage, grade, multifocality, sarcomatoid dedifferentiation) and worse survival outcomes, including after adjustments for tumor pathology.
|
29291011 |
2017 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the alteration of TFR/TFH balance in UC remains unclear.
|
29109300 |
2017 |
|
Dermatitis Herpetiformis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD89 showed a significantly higher expression in DH than in IgAN.CD71 was overexpressed in DH and IgAN.
|
29417981 |
2017 |
|
Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The transferrin receptor (CD71) acts as a mesangial cell IgA receptor and its expression is upregulated in many forms of glomerulonephritis, including IgA nephropathy.
|
28750925 |
2017 |
|
Leprosy, Lepromatous
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we observed that in LL lesion cells there is an increase in the expression of proteins involved in iron metabolism such as hemoglobin (Hb), haptoglobin, heme oxygenase 1 and transferrin receptor 1 (TfR1) when compared to tuberculoid leprosy (BT) cells.
|
28684130 |
2017 |
|
Tuberculoid leprosy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we observed that in LL lesion cells there is an increase in the expression of proteins involved in iron metabolism such as hemoglobin (Hb), haptoglobin, heme oxygenase 1 and transferrin receptor 1 (TfR1) when compared to tuberculoid leprosy (BT) cells.
|
28684130 |
2017 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the mAbs, JST-TFR09, presented its greater affinity to TFR1 on ATLL cells in flow cytometry (FCM) analysis than those of commercially available anti-TFR1 antibodies and identified high expression of TFR1 in most of the acute-type ATLL cells.
|
28189691 |
2017 |
|
Zoonoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Zoonosis into humans likely occurs because the pathogenic New World arenaviruses use human transferrin receptor 1 to enter cells.
|
28645238 |
2017 |
|
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that transformed cells from a murine PTEN-deficient T-cell lymphoma model and from T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LL) cell lines overexpress CD71.
|
27736268 |
2017 |
|
Leukemic Infiltration
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Although all transplanted mice developed enlargement of the spleen and liver due to leukemic infiltration, Fli‑1 overexpression altered the hematopoietic phenotype, significantly increasing the expression of regulatory hematopoietic genes cKIT, SCA-1, CD41 and CD71.
|
28586009 |
2017 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, the levels of labile iron pool and the functions of transferrin receptor-1 on cholangiocarcinoma development were also identified.
|
28671021 |
2017 |
|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Microarray profiles in CCA samples (n = 104) showed decreased H ferritin, hepcidin and ferroportin expression in tumours respect to surrounding liver, whereas transferrin receptor was up-regulated.
|
29247214 |
2017 |