TFRC, transferrin receptor, 7037

N. diseases: 359; N. variants: 40
Disease: Hyperinsulinism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 GeneticVariation disease BEFREE PA also translocated the tfR1 by stimulating calcium influx, but the calcium chelator, BAPTA-AM, dramatically reduced iron overload by inhibiting tfR1 translocation and ultimately increased insulin sensitivity. 30207798 2019
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 Biomarker disease BEFREE In these C57BL/6J mice, sildenafil was associated with impaired insulin sensitivity at P90 (p = 0.020) but increased insulin resistance at P150 (p = 0.019). 30292428 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 AlteredExpression disease BEFREE It was found that long-lasting hyperinsulinemia significantly increased TFR1 expression in the liver and induced mild-to-moderate hepatic iron overload, which was accompanied by a normal level of serum iron. 25385842 2014