|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.
|
31518742 |
2019 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of ABCB7 in H9C2 cells and stimulation with angiotensin II resulted in increased ROS levels, ferritin, and transferrin receptor expression and iron overload in both mitochondria and cytoplasm.
|
31511561 |
2019 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transferrin Receptor 1 was decreased as expected, following iron overload.
|
30321179 |
2018 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low hepcidin/ferritin ratio and elevated soluble transferrin receptor detected in our GPI-deficient patients suggest disturbed balance between erythropoiesis and iron metabolism contributing to iron overload.
|
28803808 |
2018 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.
|
29395073 |
2018 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group.
|
30027360 |
2018 |
|
Iron Overload
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Soluble form of transferrin receptor-1 level is associated with the age at first diagnosis and the risk of therapeutic intervention and iron overloading in patients with non-transfusion-dependent thalassemia.
|
28707012 |
2017 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels.
|
28671201 |
2017 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings strongly suggest that overexpressed TfR1 may play a regulatory role contributing to iron overload and anemia in β-thalassemic mice.
|
28151426 |
2017 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Type 2 transferrin receptor (TFR2) participates in cellular iron overload and is related to cardiovascular disease.
|
23751596 |
2014 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was found that long-lasting hyperinsulinemia significantly increased TFR1 expression in the liver and induced mild-to-moderate hepatic iron overload, which was accompanied by a normal level of serum iron.
|
25385842 |
2014 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the degree of iron overload in thalassemia intermedia and major patients by measuring hepatic iron concentration in liver biopsy samples and serum ferritin, estimated erythropoietic drive by assaying soluble transferrin receptor and serum erythropoietin levels and correlated these with urinary hepcidin measurements.
|
17488680 |
2007 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For example, transferrin receptor, a gene known to control cellular iron uptake, was downregulated in the cells treated with the iron-containing PA coal in order to protect cells from iron overload.
|
12851122 |
2003 |
|
Iron Overload
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the high frequency of HFE mutations in patients with PCT and supports the hypothesis that HFE gene abnormalities might play a significant part in the PCT pathomechanism, probably through iron overload; by contrast, transferrin receptor polymorphisms do not appear to play a significant part in iron overload in PCT.
|
11260010 |
2001 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.
|
10681454 |
2000 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA).
|
10468869 |
1999 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pattern is reverted under iron overload: IRP-mRNA binding affinity is reduced, which results in efficient protein synthesis of target transcripts harboring IREs in the 5'-UTR and rapid degradation of TfR mRNA.
|
10592329 |
1999 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early in the course of genetic haemochromatosis and before the onset of hepatic fibrosis, transferrin receptor-mediated iron uptake by hepatocytes contributes to hepatic iron overload.
|
9715407 |
1998 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present investigation evaluated the serum transferrin receptor concentration in subjects with nontransfusional iron overload who were identified in two separate studies on the basis of a serum ferritin level above 400 micrograms/L.
|
8178799 |
1994 |
|
Iron Overload
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we simultaneously analyzed the hepatic content of transferrin, transferrin receptor and heavy and light ferritin subunit messenger RNAs in tissue samples obtained from subjects with normal iron balance and patients with primary or secondary iron overload.
|
1959858 |
1991 |
|
Iron Overload
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study we used immunohistochemical techniques to study transferrin-receptor expression in the gastrointestinal epithelium in normal subjects and patients with iron overload.
|
2179037 |
1990 |