Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Over the past 20 years, recombinant deoxyribonucleic acid technology has led to the cloning of three major thyroid specific protein genes (thyroglobulin, thyroperoxidase and thyrotrophin receptor), which happen to be also the main thyroid autoantigens implicated in thyroid diseases.
|
8124482 |
1994 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied the expression of the TSH receptor (TSH-R), thyroglobulin (Tg), thyroperoxidase (TPO), and calcitonin (CT) genes in a total of 53 tissues from 30 patients with thyroid carcinoma and from 9 patients with benign thyroid diseases.
|
8157713 |
1994 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Antibodies to thyroglobulin (Tg) are commonly found in patients with the autoimmune thyroid diseases Graves' disease and Hashimoto's thyroiditis as well as in individuals with apparently normal thyroid function.
|
8752947 |
1996 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
On the basis of tissue specificity of thyroglobulin gene expression and the sensitivity of the reverse transcriptase-polymerase chain reaction (RT-PCR) analysis, we performed RT-PCR using primers for thyroglobulin on blood samples from patients with thyroid disease to detect thyroglobulin RNA transcripts.
|
8957481 |
1996 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of mRNA transcripts for thyroglobulin (TG), thyroid peroxidase (TPO) and RET/PTC1 in the peripheral blood of patients with thyroid disease.
|
9508203 |
1998 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thyroglobulin messenger ribonucleic acid levels in the peripheral blood of children with benign and malignant thyroid disease.
|
11228272 |
2001 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum thyroglobulin measurement has greatly facilitated the clinical management of patients with differentiated thyroid cancer and a variety of other thyroid disorders.
|
11444170 |
2001 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases.
|
11788684 |
2002 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of our study was to evaluate Tg content in the thyroids and Tg concentrations in the serum of 108 patients suffering from benign or malignant thyroid disorders.
|
12022704 |
2002 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We compared three methods of blood collection and RNA extraction, and quantified Tg mRNA (by real time RT-PCR) in the peripheral blood of a) probands without thyroid disease (n=42), patients with b) thyroid autonomy (n=15), c) Graves' disease (n=22), d) euthyroid goiter (n=6), and in DTC-patients after thyroidectomy and radioiodine therapy e) with (n=16) and f) without (n=37) metastasis.
|
12444888 |
2002 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that detection of Tg mRNA in blood is a more sensitive marker for metastatic thyroid disease than Tg immunoassay, and appears to be unaffected by the presence of circulating anti-Tg antibodies.
|
12782763 |
2003 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: sensitive and specific markers for thyroid cancer.
|
15292293 |
2004 |
Thyroid Diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.
|
15579800 |
2004 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that the molecular detection of circulating thyroid cancer cells by RT-PCR for TSHR/Tg mRNA complements FNA cytology in the preoperative differentiation of benign from malignant thyroid disease and their combined use may save unnecessary surgeries.
|
15687333 |
2005 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis.
|
17644307 |
2007 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of the quantification of Tg mRNA from 20 healthy subjects and 47 subjects with thyroid disease was carried out by real-time PCR.
|
18243140 |
2008 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Thyroglobulin mRNA expression in peripheral blood lymphocytes of healthy subjects and patients with thyroid disease.
|
18243140 |
2008 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our objective was to examine the prevalence of pendrin antibodies in autoimmune thyroid diseases and compare with that of thyroglobulin, thyroperoxidase, TSH receptor, and sodium iodide symporter antibodies.
|
19050049 |
2009 |
Thyroid Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations of the thyroglobulin gene and its relevance to thyroid disorders.
|
19633549 |
2009 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thyroglobulin (TG) is known to be associated with autoimmune thyroid disorders and thus exon 33 (E33) SNP in TG was investigated.
|
26963610 |
2016 |
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mean and median serum Tg levels were higher among participants with abnormal thyroid structure/function.
|
28505591 |
2017 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We calculated the rate of these thyroid diseases and positive antibodies to thyroglobulin (ATGAb), thyroid peroxidase (TPOAb) in SLE patients grouped by the presence of overlap syndrome and anti-dsDNA antibody.
|
28712818 |
2019 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The serum Tg level reflects abnormal thyroid function and is a sensitive functional biomarker of iodine nutrition status.
|
28756810 |
2017 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In Kenya and Tanzania: (i) median UIC was well above thresholds for adequate iodine nutrition in all groups and exceeded the threshold for excess iodine intake in SAC; (ii) iodine concentrations >40 mg of iodine/kg were found in approximately 55% of household salt samples; (iii) iodine concentrations ≥10 μg/L were detected in 9% of drinking water samples; (iv) Tg was elevated in all population groups, but the prevalence of thyroid disorders was negligible, except that 5-12% of women of reproductive age had subclinical hyperthyroidism and 10-15% of PW were hypothyroxinemic.
|
30019625 |
2018 |
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The prevalence of thyroid disease (TD) (OR: 3.932; 95% CI: 2.230-6.933), autoimmune TD (OR: 5.879; 95% CI: 2.682-12.885), anti-thyroperoxidase (TPO) antibody (OR: 3.838; 95% CI: 2.968-4.963), and anti-thyroglobulin antibody (OR: 3.513; 95% CI: 2.346-5.260) was significantly higher in vitiligo patients than in controls.
|
30698146 |
2018 |