|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
A different antibody with unusual features of bispecificity for both TPO and thyroglobulin may play protective role in Hashimoto's disease.
|
30742860 |
2019 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Female NOD mice were immunized twice with thyroglobulin and adjuvant to induce the experimental HT model.
|
31729993 |
2019 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, we investigated the likely association between Hashimoto's disease and BD through the extra-thyroidal localisation of thyroid-stimulating hormone receptor (TSH-R) and thyroglobulin (TG) in limbic regions of normal and bipolar human adult brain.
|
31197680 |
2019 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT.
|
30332318 |
2019 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model.
|
30971749 |
2019 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fourteen patients (82.4%) had anti-thyroglobulin antibody and were confirmed to have Hashimoto's thyroiditis through microscopic analysis.
|
29093307 |
2018 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
CTD_human |
Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice.
|
30373627 |
2018 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
To study the prevalence of Hashimoto thyroiditis (HT), anti-thyroid autoantibodies (anti-thyroglobulin or TgAb and thyroperoxidase or TPOAb) in systemic lupus erythematosus (SLE) patients.
|
28544477 |
2018 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
She had positive anti-thyroglobulin antibodies and anti-thyroid peroxidase antibodies with slightly elevated thyroid-stimulating hormone (9.048 μU/mL), and was diagnosed as chronic thyroiditis with subclinical hypothyroidism before nivolumab therapy.
|
29343652 |
2018 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Most importantly, only Tfh17 cell percentages were positively correlated with anti-thyroglobulin and anti-thyroid peroxidase antibody levels and were negatively correlated serum free T3 and free T4 levels in HT patients.
|
30345813 |
2018 |
|
Hashimoto Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene.
|
28942902 |
2018 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion.
|
28217937 |
2017 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
SNPs in the TG gene were associated with the development of HD and GD, the intractability of GD, and the levels of TG mRNA expression, serum TG, and serum TgAb.
|
28675712 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The frequency of TPO- and Tg-specific CD8+ T cells in PTC patients was largely increased compared with healthy controls (TPO and Tg, P < 0.005 and P < 0.005) and was similar to those in HT patients.
|
27860539 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Healthy female Wistar rats were randomly divided into ten exposure groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 mg/kg/d DBP, (D) 50 mg/kg/d DBP, (E) TG-immunized group, (F) TG- combined with 0.5 mg/kg/d DBP, (G) TG- combined with 5 mg/kg/d DBP, (H) TG- combined with 50 mg/kg/d DBP, (I) TG- combined with 50 mg/kg/d DBP plus 100 mg/kg/d vitamin C; (J) 100 mg/kg/d vitamin C. We showed that oral exposure DBP can aggravate CLT in rats.
|
29133889 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Instead, our finding that low dietary Se potentiates the development of autoantibodies to Tg and TPO in females is consistent with reports in humans of an increased prevalence of autoimmune thyroiditis in low-Se regions.
|
28938453 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis.
|
28768936 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In FNAC studies, the association between HT and PTC is based on the comparison of anti-thyroid autoantibodies (ATA) (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb]), thyroid function (TSH), and cytology with histology of thyroid nodules and lymphocytic thyroid infiltration (LTI) of operated thyroid glands.
|
28868258 |
2017 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
For the first time we identified a small molecule that can block Tg peptide binding and presentation to T-cells in autoimmune thyroiditis.
|
26703475 |
2016 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum immunoglobulin G antibodies against H pylori (enzyme-linked immunosorbent assay), CagA protein (Western blot assay), circulating antibodies to thyroid antigens, mainly thyroperoxidase (TPOAbs) and thyroglobulin (TgAbs), were tested in 101 females with HT and 111 non-HT control women without a history of autoimmune disease.
|
27442635 |
2016 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thirty-nine microRNAs were differentially expressed in HT (Fold change ≥2, P < 0.05) and miR-142-5p, miR-142-3p, and miR-146a were only high expression in HT thyroid gland (P < 0.001). miR-142-5p, which was expressed at high levels in injured follicular epithelial cells, was also detected in HT patient serum and positively correlated with thyroglobulin antibody (r ≥ 0.6, P < 0.05).
|
27277258 |
2016 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thyroid peroxidase and thyroglobulin antibodies are present in the majority of HT patients and help with management decisions.
|
26361257 |
2015 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The thymuses of these DS individuals contained significantly lower levels of AIRE and thyroglobulin, to which tolerance is typically lost in autoimmune thyroiditis leading to hypothyroidism.
|
25217160 |
2014 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study was undertaken to investigate if any specific KIR gene(s) is associated with the susceptibility to Hashimoto's thyroiditis (HT), an inflammatory disease characterized by lymphocytic infiltration of the thyroid gland and the presence of autoantibodies directed against thyroglobulin and/or thyroid peroxidase.
|
24174177 |
2014 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
After identifying HLA-DRB1∗03:01 (HLA-DR3) and H2E(b) as susceptibility alleles for Tg-induced experimental autoimmune thyroiditis in transgenic mouse strains, we searched for naturally processed T cell epitopes with MHC class II-binding motif anchors and tested the selected peptides for pathogenicity in these mice.
|
21683551 |
2011 |