TG, thyroglobulin, 7038

N. diseases: 240; N. variants: 43
Disease: Autoimmune thyroiditis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model. 30971749 2019
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease CTD_human Exposure to DBP and High Iodine Aggravates Autoimmune Thyroid Disease Through Increasing the Levels of IL-17 and Thyroid-Binding Globulin in Wistar Rats. 29385629 2018
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Instead, our finding that low dietary Se potentiates the development of autoantibodies to Tg and TPO in females is consistent with reports in humans of an increased prevalence of autoimmune thyroiditis in low-Se regions. 28938453 2017
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE For the first time we identified a small molecule that can block Tg peptide binding and presentation to T-cells in autoimmune thyroiditis. 26703475 2016
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 AlteredExpression disease BEFREE The thymuses of these DS individuals contained significantly lower levels of AIRE and thyroglobulin, to which tolerance is typically lost in autoimmune thyroiditis leading to hypothyroidism. 25217160 2014
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE After identifying HLA-DRB1∗03:01 (HLA-DR3) and H2E(b) as susceptibility alleles for Tg-induced experimental autoimmune thyroiditis in transgenic mouse strains, we searched for naturally processed T cell epitopes with MHC class II-binding motif anchors and tested the selected peptides for pathogenicity in these mice. 21683551 2011
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis. 21349803 2011
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Our work shows the association between the thyroglobulin gene and autoimmune thyroiditis and reinforce that thyroglobulin is a thyroid-specific susceptibility gene for this disease. 20960158 2010
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE In conclusion, our work showed the association between the thyroglobulin gene and autoimmune thyroiditis in Argentinian population and supports the described evidence of thyroglobulin as a thyroid-specific gene linked to AITD. 20972722 2010
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Subclass analysis of thyroglobulin autoantibodies indicated that IgG2 was dominant in autoimmune thyroiditis. 20087681 2010
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. 18489063 2008
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE It has been reported that serum of patients with RTH lacks autoantibodies against thyroglobulin (Tg) and thyroid peroxidase (TPO), except in rare cases where there is co-occurrence of coincidental autoimmune thyroiditis. 16723809 2006
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice. 15927791 2005
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Upon immunization with a suboptimal dose of mouse thyroglobulin, IL-12 transgenic mice developed a lymphocytic thyroiditis that was more frequent and severe than that observed in wild-type littermates. 15860554 2005
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 GeneticVariation disease BEFREE Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. 15242677 2004
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Thus, both HLA-DR and -DQ polymorphism exists for hTg in autoimmune thyroiditis. 12039412 2002
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: thyroiditis transfer with Vbeta8+ T cells. 11716530 2001
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 Biomarker disease BEFREE Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen. 9064334 1996
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.400 GeneticVariation disease BEFREE Although GD patients have a higher expectancy for development of autoimmune disorders, and in our 50 patients thyroglobulin and/or microsomal antibodies were detected in 20 (i.e., 40%), we failed to find any increased frequency of specific HLA antigen types known to be associated with juvenile autoimmune thyroiditis. 7834897 1994