|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study is aimed at investigating the anti-fibrotic potential of Niclosamide in TGF-β1 induced in vitro model of PF and 21-day model of Bleomycin induced PF in vivo respectively.
|
30611787 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Triptolide protects against TGF-β1-induced pulmonary fibrosis by regulating FAK/calpain signaling.
|
31777561 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, the <i>in vitro</i> effects of raltegravir (RAV) on transforming growth factor beta 1 (TGF-β1)-induced pulmonary fibrosis on L929 mouse fibroblasts were investigated.
|
31481891 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Yangyin Yiqi Mixture Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through Inhibiting TGF-β1/Smad Pathway and Epithelial to Mesenchymal Transition.
|
30719057 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Histopathology of skin and lungs from normal C57BL6/J mice treated with TGF-β1 showed profound dermal fibrosis and peribronchial and diffuse interstitial lung fibrosis.
|
30470772 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alleviation of Inflammatory Response of Pulmonary Fibrosis in Acute Respiratory Distress Syndrome by Puerarin via Transforming Growth Factor (TGF-β1).
|
31471534 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Bleomycin (BLM) was used to induce PF in SD rats and in vitro PF model was established by using TGFβ1-induced RLE-6TN cells. miR-205 mimics were used for overexpression of miR-205.
|
31820686 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results reveal that accumulation of extracellular ADO promotes the process of the fibroblast-to-myofibroblast transition via A<sub>2B</sub>AR/TGF-β1/Fstl1 signaling in MWCNT-induced lung fibrosis.
|
30922349 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The expression of caveolin-1 in the lung tissues is important to prevent the fibrogenic actions of TGF-β1 in lung fibrosis of different etiology including idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease and allergen-induced airway remodeling.
|
31629729 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We show that the Gls1 inhibitor, CB-839, is therapeutically efficacious in treating both bleomycin- and transforming growth factor-β1-induced pulmonary fibrosis.
|
30943369 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to explore the roles of transforming growth factor-β1 (TGF-β1), mitogen-activated protein kinase (MAPK) pathway and MMPs/TIMPs balance in Nano NiO-induced pulmonary fibrosis.
|
30810263 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, unlike normal lung fibroblasts, the relationship between pirfenidone responses of TGF-β1-induced human fibrotic lung fibroblasts and lung fibrosis has not been elucidated.
|
31185973 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, miR-627 may be a potential agent that targets HMGB1 to inhibit its expression, thereby improving TGF-β1-induced PF in vitro.
|
30536600 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We demonstrate in a model of adenoviral gene transfer of active TGF-β1 that established lung fibrosis was accompanied by elevated serum Flt3L levels and subsequent accumulation of CD11b<sup>pos</sup> DC in the lungs of mice.
|
31076499 |
2019 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFβ1-Smad2/3 axis.
|
30030077 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Follistatin-like 1 (FSTL1) is a novel profibrogenic factor that induces pulmonary fibrosis (PF) through the transforming growth factor-beta 1 (TGF-β1)/Smad signaling.
|
30082522 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
PD-1 up-regulation on CD4<sup>+</sup> T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
|
30257954 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, GPS significantly downregulated the expression of TGF-β1 and CTGF in lungs of PF mice.
|
29278701 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Compared to mice only treated with LPS, LPS-treated mice in the presence of juglanin developed less lung fibrosis with lower levels of α-smooth muscle-actin (α-SMA), collagen type I, collagen type III, and transforming growth factor-β1 (TGF-β1).
|
29532887 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We evaluated the microbial community in lung tissues from IPF and from human transforming growth factor-β1 (TGF-β1) transgenic mice with lung fibrosis by oligotyping.
|
30233503 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, siRNA-mediated inhibition of Fzd10 prevented TGF-β1-induced myofibroblast differentiation of LR-MSCs in vitro and impaired bleomycin-induced pulmonary fibrosis.
|
29844390 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We also investigated its anti-pulmonary fibrosis ability on transforming growth factor beta 1 (TGF-β1)-stimulated pulmonary epithelial cells and fibroblasts in vitro and on bleomycin (BLM)-induced pulmonary fibrosis in vivo.
|
29990528 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Irradiation resulted in significantly increased mortality and pulmonary fibrosis in wild-type mice that was associated with elevated lung expression of TGF-β1 downstream target genes and cell death compared with irradiated syndecan-2 transgenic mice.
|
28886261 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
lncRNAPCAT29 inhibits pulmonary fibrosis via the TGF‑β1‑regulated RASAL1/ERK1/2 signal pathway.
|
29620190 |
2018 |
|
Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Prodigiosin Alleviates Pulmonary Fibrosis Through Inhibiting miRNA-410 and TGF-β1/ADAMTS-1 Signaling Pathway.
|
30157485 |
2018 |