|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Taken together, our study indicates that Smad2/3/SphK1/S1P/Notch3 pathway mediates TGF-β1-induced PASMC proliferation and suggests this pathway as a potential therapeutic target in the prevention and treatment of pulmonary hypertension.
|
30430898 |
2020 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Transforming growth factor-beta1 (TGF-beta1), a multifunctional cytokine with fibrogenic properties, has been implicated in the pathogenesis of the vascular and target organ complications of hypertension.
|
9931116 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
TGFB1 rs1800469 polymorphism was observed to be associated with IA through co-modifying factors such as hypertension and gender.
|
26198819 |
2015 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Hypertension was associated with the CC genotype and C allele for IL-10 -592C/A polymorphism (p = 0.013 and p = 0.009) and higher frequencies of T (p = 0.047) and C (p = 0.033) alleles of the TGF-β1 codon 10T/C and IL-10 -819T/C polymorphisms, respectively.
|
26064986 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression.
|
11682445 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renal processing of albumin in diabetes and hypertension in rats: possible role of TGF-beta1.
|
12481143 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
These results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women.
|
12032592 |
2002 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways.
|
27297622 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
MiR-21 regulates pulmonary hypertension in rats via TGF-β1/Smad2 signaling pathway.
|
31115027 |
2019 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF-α neutralization reduced hypertension, albuminuria and renal inflammation and fibrosis, which were coupled to a reduction in renal NF-ĸB activation, inflammatory markers expression, TGF-β1 and ET-1 production, and an increase in NO release.
|
22813949 |
2012 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We assessed the association between 5 well-defined polymorphisms of the transforming growth factor-β1 (TGFB1) gene and coronary artery disease (CAD) among patients with hypertension from northeast China.
|
25155040 |
2015 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage.
|
18821144 |
2008 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The present study tested the hypothesis whether elevated TGF-β1 levels can predict the development of hypertension.
|
28575138 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The interaction between hypoxia and TGF-beta1 may be particularly relevant to pulmonary hypertension.
|
12225948 |
2002 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
GSPE decreased oxidative stress associated with hypertension in SHR and suppressed the increased expression of TGF‑β1, which blocked the translocation and differentiation of adventitia fibroblasts and eventually inhibited collagen hyperplasia in the blood vessel.
|
28447711 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It was concluded that the the MRs-redox signalling pathway is involved in TGF-β1-induced renal tubular EMT and renal inflammation/fibrosis in AngII-induced hypertension.
|
29863758 |
2018 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
CTD_human |
Before these experiments, there was no information available that would provide a basis for predicting whether or not TGF-beta(1) expression induces fibroproliferative lung disease in fibrogenic-resistant TNF-alphaRKO mice, an increasingly popular animal model.
|
11472967 |
2001 |
|
Lung diseases
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This study examined whether or not components of the Shh signalling pathway, as well as TGF-beta1, are expressed in human fibrotic lung disease (cryptogenic fibrosing alveolitis and bronchiectasis) and in murine experimental models of fibrotic and non-fibrotic chronic pulmonary inflammation.
|
12635140 |
2003 |
|
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These findings support the concept that TGFB1 gene variants appear to be important genetic modifiers of lung disease progression in CF.
|
19009622 |
2008 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
These data suggest that the beneficial anti-fibrotic effects of SAP in TGFβ(1)-induced lung disease are via modulating monocyte responses.
|
21044893 |
2011 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
RGD |
Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats.
|
19639047 |
2009 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
LHGDN |
These findings provide evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function.
|
18292811 |
2008 |
|
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Emerging data indicate that non-CFTR genetic variants contribute to at least half the variability in pulmonary disease severity, and genetic variation in transforming growth factor beta1 clearly modifies the severity of cystic fibrosis lung disease.
|
17053491 |
2006 |
|
Lung diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In summary, the results confirm the hypothesis that TGF-beta1 polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in whites.
|
19349911 |
2009 |
|
Lung diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
These results demonstrate that TGFB1 is a modifier of CF lung disease and reveal a previously unrecognized beneficial effect of TGFB1 variants upon the pulmonary phenotype.
|
18424453 |
2008 |