Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In this study, we performed data mining in the Metabolic gEne RApid Visualizer (MERAV) database and found that Slit2 and TGF-β1 (Transforming growth factor-β1) are highly expressed in carcinomas relative to those in tumor-free tissues from healthy volunteers or wild type mice.
|
31242633 |
2019 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
TGF-β1 is a multifunctional cytokine that acts as both a tumor suppressor and a stimulator of cancer development; it has been shown to influence risk of numerous other carcinomas including lung, breast and prostate cancer.
|
27733130 |
2016 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
TGF-β1, a potent EMT (epithelial-mesenchymal transition) inducer present in the tumor microenvironment, is involved in the metastasis and progression of various carcinomas, including esophageal squamous cell carcinoma (ESCC).
|
25544767 |
2015 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The moderate overexpression of TGF-β1 and TβRII mRNA in PTC tissues (61.5% and 62.5%, respectively), counteracted their high overexpression in FTC tissues (100% and 100%, respectively), while EGFR overexpression was similar in both carcinomas.
|
24973511 |
2014 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
CAF from low-grade but not high-grade carcinomas required insulin-like growth factor 1 and transforming growth factor beta 1 to stimulate carcinoma growth.
|
23056402 |
2012 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transforming growth factor-beta1 (TGF-beta1) is overexpressed in a variety of malignant epithelial tumors and was suggested to be a marker of colorectal cancer.
|
19724928 |
2009 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Down-regulated genes in CVX included transforming growth factor beta 1, transforming growth factor alpha, CFLAR, serine proteinase inhibitors (SERPING1 and SERPINF1), cadherin 13, protease inhibitor 3, keratin 16, and tissue factor pathway inhibitor-2 (TFPI-2).
|
15629771 |
2005 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of TGF-beta(1) mRNA in 108 paraffin-embedded cervical carcinomas was detected by mRNA in situ hybridization.
|
15386352 |
2004 |
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas.
|
12692838 |
2003 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of TGF-beta(1) mRNA in 108 paraffin-embedded cervical carcinomas was detected by mRNA in situ hybridization.
|
12514788 |
2002 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study we examined the coordinated expression of transforming growth factor-beta-1 (TGF-beta1), its signaling receptors, and its downstream mediator-connective tissue growth factor (CTGF)--and their impact on tumor progression and fibrogenesis in esophageal carcinomas.
|
11910473 |
2002 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, endogenous TGFbeta appears to be necessary for the progression of these two carcinomas.
|
12032856 |
2002 |
Carcinoma
|
0.400 |
Therapeutic
|
group |
CTD_human |
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
|
12417722 |
2002 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Loss of TGFbeta-IIR expression was significantly correlated with diffuse-type carcinomas according to the Lauren classification as well as with signet ring cell carcinomas and a lower grade of differentiation.
|
12174910 |
2002 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Carcinomas often secrete excess TGF-beta1 and respond to it by enhanced invasion and metastasis.
|
11684442 |
2001 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas.
|
11408925 |
2001 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The presence of the anti-inflammatory cytokine TGF-beta(1) in cervical carcinomas was confirmed by RNA in situ hybridization on tissue sections of carcinomas from which the CCCL originated.
|
11606077 |
2001 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
K-ras mutations occurred more frequently in MSS/MSI-L carcinomas (26%) than in MSI-H colorectal tumors (10%), the latter showing a high frequency of TGFbeta type II frameshift mutations (82%).
|
10601563 |
2000 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Nodal involvement correlated with PDGF-A and TGF-beta1 mRNA expression in early and advanced carcinomas, respectively.
|
10562360 |
1999 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Urokinase-type-plasminogen-activator (uPA) production by human breast (myo) fibroblasts in vitro: influence of transforming growth factor-beta(1) (TGF beta(1)) compared with factor(s) released by human epithelial-carcinoma cells.
|
9626349 |
1998 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We previously detected elevated transforming growth factor beta-1 (TGF-beta1) serum levels in patients with invasive bladder carcinomas.
|
9192977 |
1997 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alterations of transforming growth factor-beta 1 receptor type II occur in ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carcinomas, but not in gastric neoplasms.
|
9183654 |
1996 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The induction of TGF beta 1 mRNA by HMBA along with the parallel biological effects of HMBA and exogenously applied TGF beta 1 on resected carcinomas and on HT29 cells suggest that the effects of HMBA on colon carcinoma cells may be mediated in part by induction of TGF beta 1.
|
2295065 |
1990 |