Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The quantification of inflammatory cells and the expression of IL-6, TNF-α, TGF-β1 and bFGF were increased in diabetes and periodontitis.
|
31461798 |
2020 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A statistically significant change in the transcription activity of TGFβ1 in patients with and without diabetes (P = 0.018) and patients with and without metabolic syndrome (P = 0.023) was shown that on the 84th day of therapy.
|
30350412 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMP‑2 expression was decreased, and the expressions of WISP‑1, TIMP‑2, collagens, and canonical Wnt and TGF‑β1/Smad3 pathway‑related proteins were increased in the myocardia of the diabetes model rats.
|
31198980 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These changes also correlated with increased TGFβ1 activity, gene expression in the left kidney and elevated active TGFβ1 in the plasma of T1DM rats compared to control.
|
29476359 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β1 decreased in diabetes fracture patients.
|
30338820 |
2018 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Total glomeruli number in D and DH, were increased by ASE that also reduced renal fibrosis in both groups by decreasing collagen IV and TGF-β1 expression.
|
28105508 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide the first in vivo evidence that TGF-β1/Smad is a key component of intestinal tissue remodeling in diabetes.
|
29227005 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, pathological changes, expression of COL4 a1-a5 chains (<i>Col4a1-a5</i>), COL4 distribution and protein and TGFB1 and SMAD3 protein were first assessed in a rat model of diabetes.
|
29844093 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that curcumin suppresses diabetes-associated collagen synthesis in rat myocardium not only by inhibiting TGF-β1 production and canonical Smad signaling but also by blocking the non-canonical AMPK/p38 MAPK pathway.
|
28905939 |
2018 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
More importantly, clinical research revealed that gradually decreased DNA methylation in the TGFβ1 regulatory region was also present in patients with diabetes and DN.
|
29705354 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-β1, and extracellular matrix metalloproteinases in rats.
|
28220578 |
2017 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus we propose that Cx43 might enhance the activation of Nrf2/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2, and then reduce expression of FN, ICAM-1 and TGF-β1, ultimately attenuating renal fibrosis in diabetes.
|
27840317 |
2017 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a streptozotocin-induced diabetes mouse model, Nrf2(-/-) mice have delayed wound closure rates compared with Nrf2(+/+) mice, which is, at least partially, due to greater oxidative DNA damage, low transforming growth factor-β1 (TGF-β1) and high matrix metalloproteinase 9 (MMP9) expression, and increased apoptosis.
|
26718502 |
2016 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.
|
25592103 |
2015 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indeed, DHT counteracted the effect of diabetes on the mechanical nociceptive threshold, pre- and post-synaptic components, glutamate release, astrocyte immunoreactivity, and expression of interleukin-1β (IL1β), while 3α-diol was effective on tactile allodynia threshold, glutamate release, astrocyte immunoreactivity and the expression of substance P, toll-like receptor 4, tumor necrosis factor-α, transforming growth factor β-1, IL1β, and translocator protein.
|
24424289 |
2014 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the influence of cardiovascular risk factor diabetes on TGF-β1-induced monocyte migration remains to be elucidated.
|
21478266 |
2011 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we determined whether there is an association between serum levels of TGF-beta1 and the risk factors for progression of clinically relevant renal disorders in 186 black and 147 white adults, none of whom had kidney disease or diabetes.
|
19279557 |
2009 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since TGF-beta1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-beta1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes.
|
19786738 |
2009 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
|
19553350 |
2009 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Statistical analysis of genotype frequencies made separately for the underlying renal disease (diabetes or glomerulo-nephritis) revealed the same linkage trend: TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG were associated with type 2 diabetic nephropathy (p<0.001 and p<0.05, respectively) and chronic glomerulonephritis (p<0.001 and p<0.01, respectively).
|
17173255 |
2007 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We did not prove the association of TGF-beta1 polymorphisms and lung function in CF, however, the TT (codon 10)/GG (codon 25) genotype was preferentially associated with CF-related liver disease and diabetes.
|
17052957 |
2006 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Renal processing of albumin in diabetes and hypertension in rats: possible role of TGF-beta1.
|
12481143 |
2003 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results also suggest that TGF-beta1 works antiatherogenically at early stages of diabetes by increasing NO production, whereas prolonged elevation of TGF-beta1 functions atherogenically by inhibiting endothelial cell growth.
|
11384198 |
2001 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest a systemic bias towards reduced production of T-helper cell type 2 cytokines (IL-4 and TGF-beta 1) during the autoimmune process, but there was also a reduced level of IFN-gamma expression in the periphery at the onset of clinical diabetes.
|
11309160 |
2001 |