Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent.
|
31470810 |
2019 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we observed that HCV infection induces microRNA-192 (miR-192) expression, which in turn upregulates transforming growth factor β1 (TGF-β1) in hepatocytes.
|
30753992 |
2019 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Concomitantly, there was an increase in the relative quantity of miRNA-21 (P = .001*) and serum levels of TGF-β1 ( P = .337) among HCV patients after receiving treatment.
|
31368531 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Role of Signal Transducer and Activator of Transcription 5 and Transforming Growth Factor-β1 in Hepatic Fibrosis Induced by Chronic Hepatitis C Virus Infection in Egyptian Patients.
|
29402841 |
2018 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined unfavorable TNFα (GA/AA) and TGFβ1 (CT/TT) genotypes were highly associated with abnormal liver function parameters and were significantly higher in high activity (A2-A3) and late fibrosis (F2-F4) HCV patients (p = 0.023, 0.029).
|
28151059 |
2017 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, rs1800469 in TGFB1 was associated to hepatic decompensation in chronic hepatitis C, while the other 11 described polymorphisms must be evaluated in a larger cohort to determine the possible role of vitamin D in hepatitis C.
|
28703134 |
2017 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the cases and healthy controls, there was a significant association between the TGF-β1 C-509T variants and increased HCC susceptibility for two models involving HCV-infected subjects.
|
27596296 |
2016 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HBV and hepatitis C virus (HCV) serological markers, sFas and TGF-β1 levels, and HBV load were evaluated in 116 patients.
|
25990938 |
2015 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of TGF-β1, hepatitis B surface antigen, and anti-hepatitis C virus in all serum samples were detected using the enzyme-linked immunoassay method, and presence of hepatitis B virus (HBV) DNA was determined using polymerase chain reaction amplification.
|
26345741 |
2015 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we confirmed that the TGF-β1 polymorphism 509 C>T is associated with the risk of HCC in HCV-infected patients.
|
25966218 |
2015 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study investigated the relationship between pretreatment COX-2 and TGF-β1 hepatic expression in HCV genotype 4 and the virological response to interferon therapy.
|
24496160 |
2014 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the usefulness of serum Transforming growth factor-beta1 (TGF-β1), Glypican-3 (GPC3), and Golgi protein-73 (GP73) mRNAs as early biomarkers in HCC Egyptian patients chronically infected with hepatitis C virus (HCV) in comparison with serum alpha-fetoprotein (AFP).
|
24186850 |
2013 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that inheritance of IL28B CT and TT, TGF-β1 CT and TT and TNF-α AG and AA genotypes which appear to affect the cytokine production may be associated with susceptibility to HCV infection and resistance to combined antiviral therapy.
|
23219017 |
2013 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TGF-β1-509 and TNF-α-308 genes polymorphisms are associated with risk of liver cirrhosis and HCC in patients with chronic HCV infection.
|
22682513 |
2012 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicated that lumican is upregulated in clinical samples of hepatitis C virus infection, in experimental rodent models of chronic and acute liver injury and could additionally be induced in vitro in response to the pro-fibrotic cytokine transforming growth factor β1 (TGFβ1) and to lipotoxic palmitic acid.
|
23007134 |
2012 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated MAGE-4 mRNA, TGFβ1 and AFP in peripheral blood as potential biochemical markers for diagnosis and prognosis of some complications of HCV infection.
|
22653756 |
2012 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 192 patients with a recurrence of HCV infection after LT were genotyped for TGF-β1 codon 10 (C→T) and codon 25 (G→C) using the polymerase chain reaction.
|
21384510 |
2011 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of PD-L1/2, IL-10, and TGF-β1 increased expansion of CD4+ T cells in patients with chronic HCV, whereas inhibition of IL-10 and TGF-β1 was most effective in restoring HCV-specific production of interferon gamma, IL-2, and tumor necrosis factor α.
|
21763239 |
2011 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of HIV on HCV replication was blocked by a neutralizing antibody to TGF-beta1, indicating that its effects on HCV replication are TGF-beta1 dependent.
|
18325393 |
2008 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the association between TGF-beta1 polymorphism and virologic characteristics of chronic HCV infection implicated a significant role of host genetic factors on the clinical features of CHC.
|
18940717 |
2008 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that TGF-beta1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.
|
18041006 |
2008 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
LHGDN |
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma.
|
17596875 |
2007 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Candidate genes, including myxovirus resistance-1 (Mx1), protein kinase (PKR), transforming growth factor-beta1 (TGF-beta), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma), were evaluated for associations with liver fibrosis in 374 treatment-naive patients with genotype-1 chronic HCV infection [194 Caucasian Americans (CAs) and 180 African Americans (AAs)], using a genetic haplotype approach.
|
17526009 |
2007 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
LHGDN |
Addition of blocking antibodies against transforming growth factor beta1 (TGF-beta1), -2, and -3 and interleukin-10 specifically increased the HCV-specific T-cell responses in both infected groups; however, this increase was attenuated in the group with HCV-HIV coinfection compared to HCV infection alone.
|
17376924 |
2007 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis on human ALC and HC indicated a high similarity with canine samples in TGF-beta1 expression and Smad2/3 phosphorylation.
|
16842329 |
2006 |