Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
TIEG1 Represses Smad7-Mediated Activation of TGF-β1/Smad Signaling in Keloid Pathogenesis.
|
28108300 |
2017 |
Keloid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epithelial-mesenchymal transition in keloid tissues and TGF-β1-induced hair follicle outer root sheath keratinocytes.
|
26036684 |
2016 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, herein, we investigated the effects of NLRC5 on keloid fibroblasts (KFs) and transforming growth factor-β1 (TGF-β1)-induced collagen expression and explored the underlying mechanism.
|
27525969 |
2016 |
Keloid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrated that AA inhibited TGF-β1-induced collagen and PAI-1 expression in keloid fibroblasts through PPAR-γ activation, which suggested that AA was one of the active constituents of C. asiatica responsible for keloid management, and could be included in the arsenal for combating against keloid.
|
24250248 |
2013 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
To the best of our knowledge, there is only one documented report on a relationship between TGFβ1 and keloid with no association within the Caucasian population, while there have not been any reports for SMAD4.
|
22805880 |
2012 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppression of TGF-β1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid.
|
20717830 |
2010 |
Keloid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effect of the abrogation of TGF-beta1 by antisense oligonucleotides on the expression of TGF-beta-isoforms and their receptors I and II in isolated fibroblasts from keloid scars.
|
20428796 |
2010 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, stimulating KF with TGF β1, which is known to promote collagen synthesis and keloid formation, increased expression of Collagen 1A and 3A genes accompanied by reduction in MT-2A gene expression.
|
20812968 |
2010 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, TGF-beta1 antisense oligonucleotide technology may be a potential therapeutic option for the inhibition of proteolytic tissue destruction in keloids.
|
18575776 |
2008 |
Keloid
|
0.100 |
Biomarker
|
disease |
LHGDN |
Comparison of transforming growth factor-beta/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions.
|
16277007 |
2005 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Addition of TGF-beta1 to keloid fibroblast cultures increased VEGF production by 3.5-fold, while there was a 6-fold in culture of normal fibroblasts.
|
16184401 |
2005 |
Keloid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher expressions of TGF-beta1 and c-myc in keloid were also revealed using RT-PCR and Northern blot methods.
|
15198891 |
2004 |
Keloid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was no statistically significant difference in TGF-beta1 plasma levels between patients with keloid disease and hypertrophic scar and controls.
|
12560674 |
2003 |
Keloid
|
0.100 |
Biomarker
|
disease |
LHGDN |
There was no statistically significant difference in TGF-beta1 plasma levels between patients with keloid disease and hypertrophic scar and controls.
|
12560674 |
2003 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
One group of cells (NSk, NSc and keloid) were exposed to 10 ng/mL of exogenous TGF-beta1 for 24 hours, while the other group was used as control with no exposure to exogenous TGF-beta1.
|
9450987 |
1998 |
Keloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TGF-beta 1-mediated increase in keloid fibronectin production is independent of the steroid regulatory pathway for fibronectin, which accelerates synthesis by means of a post-transcriptional mechanism.
|
1431230 |
1992 |