Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The focus of this review is to summarize findings on biomarkers of myocardial fibrosis (PICP and PIIINP), profibrotic mediators (TGF-beta1), extracellular matrix remodeling (MMP-9), myocardial stretch (BNP and NTpro-BNP), inflammation (interleukins, C-reactive protein and sCD40L), and myocardial necrosis (high-sensitivity troponin T), biomarkers, that can be used in clinical practice to stratify patients at risk for POAF.
|
28748762 |
2019 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The data showed that PCFL was significantly increased in hearts of mice subjected to MI and CFs treated with transforming growth factor-β1 (TGF-β1).
|
31220469 |
2019 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
TGF-β1 -913G/C polymorphism may be a potential prognostic biomarker for MI.
|
31147455 |
2019 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notch signaling activators and TGF-β1/Smad3 signaling inhibitors could be exploited for therapeutic intervention to inhibit myocardial fibrosis after MI.
|
30317638 |
2019 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
ADSC-exosome-induced macrophage M2 polarization was also reversed after downregulation of S1PR1 under hypoxia conditions, which promoted NFκB and TGF-β1 expression, and suppressed the MI-induced cardiac fibrosis and inflammatory response.
|
31276786 |
2019 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-133a down-regulates the mRNA and protein levels of TGF-β1 and CTGF after myocardial infarction.
|
31646592 |
2019 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Transforming growth factor (TGF)-β1 is a key regulator of ECM; therefore we hypothesize that TGF-β1 is differentially expressed in adult and fetal infarcts after MI.
|
30690019 |
2019 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Qiliqiangxin Attenuates Cardiac Remodeling via Inhibition of TGF-β1/Smad3 and NF-κB Signaling Pathways in a Rat Model of Myocardial Infarction.
|
29510381 |
2018 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Liraglutide did not change the TGF-β1 expressions while reduced the CTGF expressions in infarct and non-infarct area of mice after myocardial infarction.
|
30058704 |
2018 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we found that Nogo-C was upregulated in fibrotic hearts after myocardial infarction and in Ang II- or TGF-β1-stimulated cardiac fibroblasts.
|
29795235 |
2018 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data suggest that after MI, signaling through TGF-β1, possibly related to increased mechanical load, drives Fb activation throughout the left ventricle while regional signaling determines further maturation and extracellular matrix remodeling after MI.
|
28883544 |
2017 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RESULTS Increased connective tissues were observed in myocardial tissues at 4 weeks after infarction by HE staining, which also revealed widening of the intra-myocardial cleft, along with more inflammatory cells and fibroblast hypertrophy. miR-24 expression was significantly depressed at 2 and 4 weeks after cardiac infarction (p<0.05). mRNA levels of Furin and TGF-β1 were elevated after infarction (p<0.05).
|
28055991 |
2017 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the border area after myocardial infarction, the expression of miR‑370 decreased, while mRNA levels of TGFβ1, TGFβRII, ColIa1 and ColIIIa1 and levels of TGFβ1, TGFβRII and α-SMA proteins were all increased.
|
28350072 |
2017 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, TMP and AGS-IV synergistically inhibited LV fibrosis by attenuating MI-induced collagen deposition and elevation of transforming growth factor β1.
|
27676326 |
2017 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Using APSampler software, we found composite markers associated with MI only in patients with early onset: FGB rs1800788*T + TGFB1 rs1982073*T; FGB rs1800788*T + LPL rs328*C + IL4 rs2243250*C; FGB rs1800788*T + ENOS rs2070744*C (Fisher p values of 1.4 × 10<sup>-6</sup> to 2.2 × 10<sup>-5</sup>; the permutation p values of 1.1 × 10<sup>-5</sup> to 3.0 × 10<sup>-4</sup>; ORs = 2.67-2.54).
|
28685248 |
2017 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
There were no differences in the distribution of the Gensini score between the genotypes of the analyzed polymorphisms in FGF2, EGF, IGF1, PDFGB, and TGFB1 in the whole cohort and in the subgroup of patients without previous MI.
|
27835972 |
2016 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction.
|
27121011 |
2016 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We also found and replicated biallelic combinations of TGFB1 with FGB, TGFB1 with CRP and IFNG with PTGS1 genetic variants associated with myocardial infarction providing a detectable cumulative effect.
|
26658659 |
2015 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFβ1.
|
26319660 |
2015 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The heterozygous genotype of TGFB+868 was associated with an increased risk of IHD (OR 2.14, 95% CI 1.30 - 3.55) and MI (OR 2.42, 95% CI 1.30-4.50), compared to the homozygous genotypes combined.
|
22513132 |
2012 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients.
|
18312614 |
2008 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Increased TNF-alpha and decreased TGF-beta expression in peripheral blood leukocytes after acute myocardial infarction.
|
16718633 |
2006 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction.
|
16310260 |
2006 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study.
|
17023672 |
2006 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Positive association findings in this study suggest that TGFB1 is a susceptibility locus for myocardial infarction.
|
16543493 |
2006 |