|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy.
|
31512238 |
2020 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study verified that miR-130a-3p facilitates the TGF-β1/Smad pathway in renal tubular epithelial cells and may participate in renal fibrosis by targeting SnoN, which could be a possible strategy for renal fibrosis treatment.
|
31836508 |
2020 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that SGLT2i block basal and TGF-β1-induced expression of key mediators of renal fibrosis and kidney disease progression in two independent human PT cell lines.
|
30539648 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on results obtained with an animal model of kidney fibrosis and a proximal tubular epithelial cell line system, the authors put forward a role for MKP2 as a negative feedback regulator of TGF-β1-induced EMT and fibrosis in the kidney.
|
30760641 |
2019 |
|
Renal fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study confirmed that incremental load training may improve renal fibrosis in aged mice by regulating the TGF‑β1/TAK1/MMK3/p38MAPK signaling pathway and inducing the activation of autophagy to reduce the synthesis of extracellular matrix and delay the epithelial‑mesenchymal transition.
|
31545406 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our finding displayed a novel regulatory mechanism for TGF-β1-induced renal fibrosis, which provided a new potential therapeutic target for renal fibrosis.
|
30095214 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-β1 (TGF-β1)/Smad3-driven renal fibrosis is the common pathogenesis of obstructive nephropathy.
|
31211499 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation.
|
31059771 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the role of microRNA-130b in 1,25(OH)2D3 mediated improvement of renal fibrosis via transforming growth factor-beta 1 in a rat model of diabetic nephropathy (DN).
|
31781203 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these findings demonstrate that the inhibition of TRPM2 might protect against renal fibrosis and inflammation through impeding JNK activation regulated by TGF-β1.
|
31655312 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β1, a critical regulator of fibrosis, was used to stimulate human kidney-2 cells to establish cell model for renal fibrosis.
|
29723660 |
2019 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pink1 or Park2 gene deletion markedly increased mtROS production, mitochondrial damage, TGFβ1 expression in RTEC, and renal fibrosis in UUO.
|
31825802 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo experiments demonstrated that renal proximal tubular epithelial cell production of TGF-β1 was key to C. albicans-induced renal fibrosis and injury.
|
30127380 |
2019 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Maternal exposure to di-n-butyl phthalate promotes Snail1-mediated epithelial-mesenchymal transition of renal tubular epithelial cells via upregulation of TGF-β1 during renal fibrosis in rat offspring.
|
30453174 |
2019 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
QCF may improve renal fibrosis by regulating the expressions of TGF-β1, α-SMA and E-cadherin, and prevent the progress of kidney fibrosis.
|
26142335 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-β1 (TGF-β1) is the central mediator of renal fibrosis and numerous studies have focused on inhibition of TGF-β1 and its downstream targets for treatment of kidney disease.
|
29518614 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing Erbb4-IR blocked TGF-β1-induced collagen I and alpha-smooth muscle actin (α-SMA) expressions in vitro and effectively attenuated renal fibrosis in the UUO kidney by blocking TGF-β/Smad3 signaling.
|
29102563 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the fibrogenic cytokine TGF-β1 contributes to CsA-induced renal fibrosis, while Nrf2 modulates CsA-induced cellular oxidative stress.
|
29960018 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the effect of P311 on transforming growth factor-β1 (TGF-β1)-mediated EMT in a rat model of unilateral ureteral occlusion (UUO) renal fibrosis.
|
29436600 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we verified the interaction between novel truncated human TGF-βRII (thTβRII, Thr23-Gln166) and TGF-β1, prepared thTβRII in Escherichia coli, and assessed the effects of thTβRII on TGF-β1-induced human kidney epithelial cells (HK-2) and unilateral ureteral obstruction (UUO) model of renal fibrosis.
|
30066965 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
OA can attenuate TGF-β1 mediate EMT in renal tubular epithelial cells and may be a promising therapeutic agent in the treatment of renal fibrosis.
|
29973206 |
2018 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transglutaminase (TG) is a crosslinking enzyme that catalyzes the formation of covalent bonds between glutamine and lysine residues, and is involved in the induction of renal fibrosis via the stabilization of ECM and the activation of TGF-β1.
|
29743665 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further studies showed that inhibition of renal fibrosis in SIT-treated diabetic rats and MCs were associated with rebalancing of TGF-β1/Smad pathway.
|
29484381 |
2018 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Total glomeruli number in D and DH, were increased by ASE that also reduced renal fibrosis in both groups by decreasing collagen IV and TGF-β1 expression.
|
28105508 |
2018 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results showed that the treatment of AKBA significantly alleviated UUO-induced impairment of renal function and improved the renal fibrosis by decreasing the expression of TGF-β1, α-SMA, collagen I and collagen IV in UUO kidneys.
|
30054990 |
2018 |