Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that Wnt4 negatively regulates TGF-β1-induced fibroblast activation, which may represent a novel therapeutic strategy for the treatment and prevention of hypertrophic scars.
|
31776823 |
2020 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The research was designed to study the significance of artesunate (ART) on the expression of transforming growth factor (TGF-β1) and small mother against decapentaplegic (SMAD3) in rabbit's ear hypertrophic scar model.
|
31396694 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This optimised in vitro model has been found to hold similar properties, such as increased collagen I, interleukins and transforming growth factor beta-1 expression, compared to that observed in hypertrophic scar tissue in vivo.
|
31301289 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results showed that SnoN was downregulated in HS fibroblasts (HSFs) owing to TGF-β1/Smad-induced degradation.
|
31409891 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we show that BMN consisting of HA and bleomycin can inhibit the proliferation of human hypertrophic scar fibroblasts (hHSFs) and the secretion of transforming growth factor-β (TGF-β1) in vitro.
|
31589215 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dermal fibroblasts from human hypertrophic scar were stimulated with transforming growth factor beta 1 (TGF-β1) for 24 h and cultured in each culture medium for 72 h. We measured the hypertrophic scar (HS) formation during the skin regeneration by measuring the expression of several remodeling molecules and the effect of these conditioned media on active human HS fibroblasts.
|
31462299 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the effectiveness of combined ablative fractional CO2 laser and topically applied 5-fluorouracil (5-FU) or verapamil hydrochloride in the treatment of hypertrophic scars (HTSs) and keloids and to examine their possible effects on TGF-β1 expression.
|
30829753 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein expression difference of transforming growth factor-β1 (TGF-β1) in NS tissues and HS tissues was detected via Western blotting.
|
28933518 |
2019 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, immunohistochemical analysis indicated that Shikonin inhibited the expression of p63, cytokeratin 10, alpha-smooth muscle actin, transforming growth factor-beta 1, and collagen I, which play important roles in hypertrophic scar formation.
|
29922164 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesised that a feedback mechanism of the transforming growth factor (TGF)-β1 signalling pathway, triggered by high-level TGF-β1, activates platelet-rich plasma (PRP) release to reduce connective tissue growth factor (CTGF) production and expression of CTGF mRNA in hypertrophic scar dermal fibroblasts.
|
29781178 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of TGF-β1 was upregulated in HS tissues, and knockdown of TGF-β1 in cultured fibroblasts led to inhibition of proliferation.
|
30116380 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, a skin HS model was established in rats and the scar formation was compared between rats treated with vehicle (saline), TGF-β1, and TGF-β1 + TSP-4 shRNA.
|
30132849 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of the TGF-β1/Smad signal transduction pathway may be a potential therapeutic target for the management of HS.
|
29434689 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The sustained high expression of TGF-β1 is believed to result in the formation of hypertrophic scars.
|
30046895 |
2018 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the expression of miR‑185 was markedly suppressed, and TGF‑β1 and Col‑1 levels were increased, in HS tissues.
|
28259900 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that mast cells and chymase are present in hypertrophic scars, and chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating the TGF-β1/Smads signaling pathway.
|
29104654 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we present a TGF-β1-inhibitor-doped poly(ε-caprolactone) (PCL)/gelatin (PG) coelectrospun nanofibrous scaffold (PGT) for HS prevention during wound healing.
|
28875694 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis.
|
29113333 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we attempted to rationally derive peptide inhibitors from the complex interface of TGF-β1 with TβRII to disrupt such interaction for the suppression of fibroblast activation involved in HS.
|
28122173 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that miR-29b treatment has an inhibitory effect against scar formation via inhibition of the TGF-β1/Smad/CTGF signaling pathway and may provide a potential molecular basis for future treatments for hypertrophic scars.
|
28092445 |
2017 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, qPCR analysis of RNA samples from multiple patients confirmed dramatically increased expression of LTBP-2 and FGF-2, similar TGF-beta 1, in hypertrophic scar compared to normal skin and scar tissue.
|
26644005 |
2016 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we found both FAK and Src were activated in HS vs. normal skin (NS), NS fibroblasts treated with TGF-β1 also exhibited FAK/Src activation.
|
27181267 |
2016 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicated that miR-21 was a critical regulator for HS formation and TGF- β1/miR-21/Smad7 pathway could be a useful therapeutic target for the treatment of HS.
|
27207585 |
2016 |
Cicatrix, Hypertrophic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the up-regulation of SIRT1 not only inhibited the expression of α-SMA, Col1 and Col3 in hypertrophic scar-derived fibroblasts but also blocked the activation of TGFβ1-induced normal skin-derived fibroblasts.
|
26891034 |
2016 |
Cicatrix, Hypertrophic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
|
25938472 |
2015 |