TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Disease: Carcinoma breast stage IV ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.040 GeneticVariation disease BEFREE We sequenced cfDNA of a hormone receptor-positive, HER2-negative metastatic breast cancer (MBC) cohort with a high coverage to examine the prevalence and relevance of any detected variant. cfDNA of 44 MBC patients was isolated, followed by library construction using a customized targeted DNA panel with integrated unique molecular indices analyzing AKT1, AR, BRCA1, BRCA2, EGFR, ERCC4, ERBB2, ERBB3, ESR1, FGFR1, KRAS, MUC16, PIK3CA, PIK3R1, PTEN, PTGFR, and TGFB1. 31254045 2020
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.040 AlteredExpression disease BEFREE TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 19955655 2010
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.040 Biomarker disease BEFREE Small interfering RNA constructs targeting TGF-beta1 were validated and used to develop clonal derivatives of the metastatic breast cancer cell line MDA-MB-435. 18676771 2008
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.040 Biomarker disease BEFREE C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. 16959612 2006