Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-β1, miR-143-3p, p-Smad2, and collagens.
|
31758917 |
2020 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, anti-TLR2 antibody alleviated masson staining area, levels of TGF-β1 and Collagen I mRNA, and decreased TUNEL-positive myocardial cells and caspase-3 activity, suggesting that anti-TLR2 antibody protected cardiac cells against high-fat-induced cardiac fibrosis and cell apoptosis.
|
30877771 |
2019 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates a novel transgenic goat model of cardiac fibrosis (TGF-β1 overexpression) to demonstrate that endurance exercise in the setting of an underlying atrial myopathy increases the incidence of spontaneous AF.
|
31707807 |
2019 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human.
|
31520610 |
2019 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation in rats with AF.
|
30683806 |
2019 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats.
|
31254954 |
2019 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
M<sub>3</sub>R protein level, as identified by Western blotting, was higher in mice with excessive cardiac fibrosis and in TGF-β1-induced cardiac fibrosis as well.
|
31849653 |
2019 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In CFs, preincubation with PARP1 or mTOR inhibitors all blocked TGF-β1 induced cardiac fibrosis.
|
29278652 |
2019 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This proof-of-concept study using an in vitro experimental cell culture model identifies the protective role of simvastatin against TGF-β1-induced hVF transformation into activated myofibroblasts through activation of protein phosphatase, a novel target that can be therapeutically modulated to curb excessive cardiac fibrosis associated with maladaptive cardiac remodeling.
|
30220377 |
2018 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TGFβ1 is a key cytokine mediating cardiac fibrosis.
|
28230250 |
2018 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of IL-33/ST2 pathway factors in myocardial tissue were significantly associated with cardiac fibrosis and the expression levels of CTGF and TGFβ1.
|
29285671 |
2018 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results of the present study demonstrated that TGF‑β1/Smad signaling‑associated cardiac fibrosis is involved in the impairment of heart compliance and LV dysfunction in DbCM.
|
29138820 |
2018 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the inhibitory effect and mechanism of oxymatrine on cardiac fibrosis induced by TGF-β1.
|
30196308 |
2018 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
AT‑II induces periostin expression by regulating transforming growth factor‑β1 (TGF‑β1)/Smad signaling during cardiac fibrosis.
|
28849131 |
2017 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the role of RyR-2 in cardiac fibrosis during the development of cardiac hypertrophy remains unclear.In this study, we examined whether RyR-2 regulates TGFβ1, which is secreted from cardiomyocytes and exerts on cardiac fibrosis using cultured cardiomyocytes and cardiac fibroblasts of neonatal rats.
|
29162778 |
2017 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor β 1 (TGFβ1) is as an essential inducing factor of cardiac fibrosis.
|
28214335 |
2017 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results provide further evidence for protective effect of miR-98 overexpression on TGF-β1-induced cardiac fibrosis.
|
28251559 |
2017 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
A recent study reported that deficiency of miR-378a contributes to cardiac fibrosis via TGF-β1-dependent paracrine mechanism.
|
27855367 |
2016 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia.
|
27380173 |
2016 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
RGD |
Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.
|
27108788 |
2016 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives.
|
19728040 |
2010 |
Cardiac fibrosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also measured cardiac TGF-beta1 protein (total and active), Smad2 phosphorylation, and MMP activity after the onset of macrophage accumulation but before the onset of cardiac fibrosis.
|
16554301 |
2006 |
Cardiac fibrosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway.
|
12154105 |
2002 |