Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, activation of the c-Jun N-terminal kinase (JNK)/c-Jun pathway was involved in the malignant transformation of HPCs. miR-199a-3p was identified as a significantly upregulated microRNA in HPCs upon HBx and TGF-β1 exposure, which were shown to promote miR-199a-3p expression via c-Jun-mediated activation.
|
31740785 |
2020 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TGF-β1 mediated radiation-induced bystander effects (RIBE) have been linked with malignant transformation and tumorigenesis.
|
30423581 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-β1.
|
28098901 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Transforming growth factor-β1 (TGF-β1) within tumor microenvironment has a pivotal function in cancer initiation and tumorigenesis, and hence this study was to observe the malignant transformation induced by TGF-β1 in an immortalized colon epithelial cell line NCM460 for better understanding the mechanisms of colon carcinogenesis.
|
27401062 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings indicate that Nrf2 and TGF-β1 both contribute to malignant transformation through distinct EMT related mechanisms accounting for an invasive phenotype.
|
26226105 |
2015 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Tissue-pair mRNA and protein analysis reveals VEGF transcriptional up-regulation and TGFB1 down-regulation that are correlated with the malignant transformation of the endometrium, while post-transcriptional mechanisms control VEGF and TGFB1 protein.
|
23176363 |
2013 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we examine the role of TGF-β1-induced L1CAM expression and macrophages in malignant transformation of intestinal epithelial cells.
|
22349829 |
2013 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
|
19435915 |
2009 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that the TGF-[beta]1 -509T allele may have a protective role in the development of colorectal cancer, possibly consistent with its role as an inhibitor of epithelial malignant transformation.
|
17214746 |
2007 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings provide for the first time evidence for the implication of YY1 in uterine cervix carcinogenesis and suggest that VEGF, TGF-beta1 and YY1 could be useful biomarkers of cervical malignant transformation as well as potential targets for therapeutic approaches.
|
17549406 |
2007 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our findings show that VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix.
|
15797633 |
2005 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop.
|
15020570 |
2004 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The disruption of the transforming growth factor beta1 (TGF-beta1) autocrine growth-suppressive circuit is a major and possibly early event mediating the malignant transformation of normal epithelia.
|
14585325 |
2003 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It is suggested that TGF beta 1 may be associated with the malignant transformation of hepatocyte or the progression of HCV-associated HCC.
|
11242803 |
2000 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The findings presented suggest that c-jun may have a role in inducing malignant transformation in RCC and a novel mechanism by which TGF-b1 may exert its anti-tumor effects, via the activation of junB.
|
1404666 |
1992 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cells became partially resistant to the inhibitory effects of TGF beta 1 on cell growth and HPV early gene expression after prolonged cultivation in vitro or after malignant transformation.
|
2168964 |
1990 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that TGF beta 1 may be an in vivo modulator of HPV infection and that loss of responsiveness to this growth inhibitory signal may be involved in HPV-associated malignant transformation.
|
2171761 |
1990 |