|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The TGF-β1/SGK1 pathway is closely related to tubulointerstitial fibrosis in T2DM rats.
|
31841202 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Roscovitine attenuates renal interstitial fibrosis in diabetic mice through the TGF-β1/p38 MAPK pathway.
|
31029000 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The mechanism underlying these effects may be related to inhibition of TGF-β1/Smad, and their downstream miR-21/PTEN signaling, leading to blocks of EMT process during RIF.
|
30304552 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
CL treatment improved TAC-induced renal dysfunction and decreased renal interstitial fibrosis (reduced expression of e-cadherin and TGFβ-1) and interstitial inflammation (decreased infiltration of ED-1-positive and osteopontin-positive cells).
|
31200653 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, in TGF-β1 stimulated HK-2 cells, AS-IV clearly inhibited the expression levels of α-SMA, vimentin, collagen I, and miR-192 in a dose-dependent fashion while increased the expression level of E-cadherin in the same manner, indicating that AS-IV functioned the inhibitory role in renal tubulointerstitial fibrosis.
|
31497219 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The results we obtained demonstrate that Nrf2 signaling pathway may perhaps offset the development of EMT, prompted by TGF-β1 and renal interstitial fibrosis.
|
31449784 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
NRK-52E cells were induced with 5 ng/mL transforming growth factor-β1 (TGF-β1) for constructing the renal interstitial fibrosis model in vitro.
|
31378905 |
2019 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
As one mechanism for the protection against diabetes-induced TIF and EMT, decreased Smad3 protein levels and, as a possible consequence, reduced TGF-β1 levels were observed in diabetic SMAD2 knockout mice.
|
29209813 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis.
|
29913155 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
We found that, compared with the IRI group, the TJ-M2010-2 group showed marked attenuation of RIF and renal function injury; decreased expression of TGF-β1, α-SMA, vimentin, MMP2 and MMP9; and increased E-cadherin expression.
|
30380557 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The nuclear transcription co-repressor Ski-related novel protein N (SnoN) is a critical negative regulator of TGF-β1/Smad signal pathway, involving in tubule epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) accumulation, and tubulointerstitial fibrosis.
|
28707079 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1.
|
30138414 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Previously, we showed that core fucosylation, an important posttranslational modification of the TGF-β1 receptors, can regulate the activation of TGF-β1 signaling in renal interstitial fibrosis.
|
29571940 |
2018 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In this study, we investigated the role of the Sirt1 activator, SRT1720, in unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis and aimed to determine whether this role depends on the inhibition of oxidative stress and the TGF-β1/CTGF pathway.
|
28339034 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
HMGB1, TGF-β1 and NF-κB may form a signaling pathway that leads to the occurrence of CAN, which induces renal interstitial fibrosis.
|
29285170 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Tubulointerstitial fibrosis that was indicated by the increases in collagen and transforming growth factor-β1 subsided by cilostazol.
|
28084586 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrated that p16 <sup>INK4a</sup> deletion largely rescued renal aging phenotypes caused by Bmi-1 deficiency, including impaired renal structure and function, decreased proliferation, increased apoptosis, senescence and SASP, DNA damage, NF-κB and TGF-β1/Smad signal activation, inflammatory cell infiltration, and tubulointerstitial fibrosis and tubular atrophy.
|
28790310 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The results of the present study further verified the therapeutic efficacy of ART in TGF‑β1‑induced renal interstitial fibrosis.
|
28990102 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
The immunohistochemical detection of Transforming growth factor β1 and monocyte chemoattractant protein-1 expression was correlated with the tubulointerstitial fibrosis grade.
|
28273242 |
2017 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
HS is able to antagonize, to some extent, tubular EMT and renal interstitial fibrosis caused by AA, which might be related to its inhibitory effects on the TGF-β1 and Snail expression.
|
26890569 |
2016 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
The effects of lefty1 were assessed by measuring the degree of tubulointerstitial fibrosis, tubular injury and atrophy, and also by monitoring the expression levels of α‑smooth muscle actin (α‑SMA), TGF‑β1, phosphorylated (p)‑Smad2/3, kidney injury molecular‑1 and endogenous lefty1.
|
26647776 |
2016 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The cells were also more prone (versus control) to TGFβ-1 induced epithelial-mesenchymal transition (EMT), a hallmark feature of the development of renal interstitial fibrosis, and characterized by development of spindle shape morphology, gene expression changes in EMT markers (Col1a3, Mmp9, Bmp7, and Ocln) and increased expression of N-Cadherin and Vimentin.
|
26172442 |
2015 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In the UUO model, administration of apelin significantly attenuated renal interstitial fibrosis, as evidenced by the maintenance of E-cadherin and laminin expression, and markedly suppressed expression of α-SMA, TGF-β1 and its type I receptor, as well as interstitial matrix components.
|
25164121 |
2014 |
|
Tubulointerstitial fibrosis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
As TGF-β1 plays a central role in the activation of fibroblasts to myofibroblasts in renal interstitial fibrosis, human primary renal interstitial fibroblasts were incubated with TGF-β1+/- the selective inhibitor of KCa3.1, TRAM34, for 48 h. Two streptozotocin-induced diabetic mouse models were used in this study: wild-type KCa3.1+/+ and KCa3.1-/- mice, and secondly eNOS-/- mice treated with or without a selective inhibitor of KCa3.1 (TRAM34).
|
24166472 |
2014 |
|
Tubulointerstitial fibrosis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis.
|
23486519 |
2013 |