|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, additional maternal zinc supplements blocked the ethanol-induced perturbations in the pup AM zinc homeostasis and TGFβ1 immunosuppression, thereby improving RSV phagocytosis and attenuating the RSV burden in the lung.
|
30580016 |
2019 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression.
|
29392336 |
2018 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, we also found that the expression of IL-33 was negatively correlated with that of TGF-β1 and chemokines that recruit regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), indicating that the IL-33/ST2 axis may also contribute to antagonizing Tregs, MDSCs, and TGF-β1-mediated immunosuppression in STS.
|
29896199 |
2018 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, this work further elucidates the mechanism of antibody-mediated blockade of TGF-β1 activation and immunosuppression by T<sub>regs</sub>.
|
30361387 |
2018 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
With respect to the pathogenesis of both sustained immunosuppression and the increased frequency of non-AIDS-related disorders, the anti-inflammatory/profibrotic cytokine, transforming growth factor-β1 (TGF-β1), which remains persistently elevated in both untreated and virally suppressed HIV-infected persons, may provide a common link.
|
29163528 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The paracrine activity of regulatory T cell-derived TGF-β1 contributes to immunosuppression and can be inhibited with anti-GARP Abs.
|
28607112 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The exhausted immune response subclass expressed many genes regulated by transforming growth factor beta 1 that mediate immunosuppression.
|
28624577 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that upregulation of tumor cell PD-L1 is a novel mechanism of TGF-β1-induced immunosuppression in NSCLC, and that treatment with M7824 has the potential to simultaneously block both tumor mesenchymalization and PD-L1-dependent immunosuppression.
|
29123964 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that cancer-secreted TGF-β1 may increase Tregs, and TGF-β1 knockdown might impair immunosuppression in the tumor microenvironment by decrease Tregs.
|
26799063 |
2016 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with 4T1/RFP bearing mice, systemic immunosuppression in 4T1/TGF-β1 bearing mice was observed, represented by a higher proportion of regulatory T cells and myeloid-derived suppressor cells and a lower proportion of activated T cells and INFγ expression in CD8(+) T cells.
|
27036297 |
2016 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor beta isoforms (TGF-β1, -β2, and -β3) are cytokines associated with a wide range of biological processes in oncology including tumor cell invasion and migration, angiogenesis, immunosuppression, as well as regulation of tumor stem cell properties.
|
26072406 |
2015 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present analysis provides clues that artesunate reverses the immunosuppression from Colon26 and RKO colorectal cancer cells by decreasing TGF-β1 and IL-10.
|
25978851 |
2015 |
|
Immunosuppression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
|
23996684 |
2014 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β1 in tumor microenvironments induces immunosuppression in the tumors and sentinel lymph nodes and promotes tumor progression.
|
24509168 |
2014 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta 1 (TGF-β1) has been reported being involved in the remodeling and immunosuppression processes of inflammatory airway diseases; understanding the regulation of TGF-β1 is therefore a key to unravel the pathomechanisms of these diseases.
|
24750111 |
2014 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor (TGF)-beta2, which we previously showed to be induced by lactic acid, is a key pathophysiological factor in glioblastoma, leading to increased invasion and severe local immunosuppression after proteolytic cleavage from its latency associated peptide.
|
24223867 |
2013 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the expression of forkhead box P3, a characteristic marker of regulatory T cells (Tregs), transforming growth factor‑β1 and interleukin (IL)‑10, inhibitory factors secreted by Tregs and inhibitory costimulatory molecules, cytotoxic T-lymphocyte antigen 4, glucocorticoid-induced TNFR-related protein and programmed cell death protein 1 was observed to be upregulated, indicating that immunosuppression of Tregs was enhanced significantly.
|
23754510 |
2013 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The multifunctional cytokine transforming growth factor-beta(1) (TGF-beta(1)) is involved in immunosuppression, stroma and extracellular matrix formation and controlling (epithelial) cell growth.
|
15386352 |
2004 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Besides controlling (epithelial) cell growth, the multifunctional cytokine transforming growth factor-beta(1) (TGF-beta(1)) is involved in the formation of stroma and extracellular matrix (ECM) and in immunosuppression.
|
12514788 |
2002 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-beta1 has a biological role for the immunosuppression of the host.
|
10448868 |
1999 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The local immunosuppression is an effect, at least in part, of the overproduction of tumor necrosis factor alpha and transforming growth factor beta1 and of the excessive formation of cis-urocanic acid.
|
7503577 |
1995 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We speculate that failure of tamoxifen therapy may be due to failure of the autocrine inhibitory functions of TGF-beta 1 either alone or in combination with paracrine stimulation of stromal cells or angiogenesis and localised immunosuppression.
|
2021547 |
1991 |