LEFTY2, left-right determination factor 2, 7044

N. diseases: 18; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0266642
Disease: Situs ambiguus
Situs ambiguus 		0.500 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.500 Biomarker disease GENOMICS_ENGLAND Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.500 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C0266642
Disease: Situs ambiguus
Situs ambiguus 		0.500 SusceptibilityMutation disease ORPHANET
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.300 Biomarker group CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C0175707
Disease: Asplenia Syndrome
Asplenia Syndrome 		0.300 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C0265357
Disease: Polysplenia Syndrome
Polysplenia Syndrome 		0.300 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C3178806
Disease: Right Atrial Isomerism
Right Atrial Isomerism 		0.300 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C3178807
Disease: Left Atrial Isomerism
Left Atrial Isomerism 		0.300 Biomarker disease CTD_human Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. 10053005 1999
CUI: C1167664
Disease: Situs ambiguous
Situs ambiguous 		0.300 SusceptibilityMutation disease ORPHANET
CUI: C4277690
Disease: Ciliopathies
Ciliopathies 		0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C4277690
Disease: Ciliopathies
Ciliopathies 		0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE Left‑right determination factor 2 (LEFTY2), a suppressor of cell proliferation and tumor growth, is a negative regulator of EC progression. 29845221 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE These findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression. 9230066 1997
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.010 AlteredExpression disease BEFREE Using western blot analysis and immunofluorescence assays, it was demonstrated that overexpression of miR‑215 markedly downregulated LEFTY2 protein expression levels in HEC‑1A cells and LEFTY2 protein expression was downregulated in EC tissues, which was inversely correlated with miR‑215 expression. 29845221 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.010 AlteredExpression disease BEFREE Using western blot analysis and immunofluorescence assays, it was demonstrated that overexpression of miR‑215 markedly downregulated LEFTY2 protein expression levels in HEC‑1A cells and LEFTY2 protein expression was downregulated in EC tissues, which was inversely correlated with miR‑215 expression. 29845221 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.010 GeneticVariation disease BEFREE Statistical analyses showed that the rs2295418 (g.C925A) variant in Lefty2 gene was obviously associated with the risk of CHD (P value = 0.016<0.05). 25111179 2014
CUI: C0018818
Disease: Ventricular Septal Defects
Ventricular Septal Defects 		0.010 AlteredExpression group BEFREE In this report, we show that the average expression of EBAF in the disease tissues of VSD patients was lower than the expression in normal fetuses without VSD. 23899608 2013
CUI: C0085261
Disease: Proteus Syndrome
Proteus Syndrome 		0.010 Biomarker disease BEFREE This overview of asymmetry addresses the following topics: chiral molecules; asymmetric signaling molecules, including N-cadherin, Shh, Fgf8, lefty1, lefty2, nodal, Pitx2, activin betaB, activin receptor IIA, and cSnR; situs abnormalities; asymmetric cell division; laterality in humans and animals; behavioral asymmetry in humans and animals; asymmetric embryopathies, including Tessier-type "clefts"; hemiasymmetries such as hemihyperplasia, hemihypoplasia, and hemiatrophy; asymmetric vascular syndromes, including Klippel-Trenaunay and Sturge-Weber syndromes; plagiocephaly of the synostotic and deformational types; somatic mosaicism, including a discussion of McCune-Albright syndrome, fibrous dysplasia, GNAS1 mutations, and Proteus syndrome. 11471152 2001
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.010 Biomarker disease BEFREE During the critical period of endometrial receptivity, ebaf protein was more abundant in patients with endometriosis who did not conceive than in patients who became pregnant. 10902804 2000
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 AlteredExpression group BEFREE However, some serous adenocarcinomas of the ovary also exhibited TGFB4 (ebaf) mRNA. 9230066 1997
CUI: C0206659
Disease: Embryonal Carcinoma
Embryonal Carcinoma 		0.010 AlteredExpression disease BEFREE The testicular tumors, seminomas and embryonal carcinomas, also expressed TGFB4 (ebaf) mRNA. 9230066 1997