Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE Here we show that R-spondin 1 (RSPO1)/LGR5 directly activates TGFβ signaling cooperatively with TGFβ type II receptor in colon cancer cells, enhancing TGFβ-mediated growth inhibition and stress-induced apoptosis. 28939678 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE Importantly, these Tgfbr2(ΔIEC) mice developed invasive colon cancer associated with chronic inflammation. 25687406 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE Here, we used the TGFBR2-deficient MSI colon carcinoma cell line HCT116 as a model system. 23468914 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 AlteredExpression disease BEFREE Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. 21454688 2011
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation disease BEFREE TGF-beta1 induced changes in cellular morphology, gene expression, motility, and invasion consistent with EMT in microsatellite stable (MSS) colon cancer cells, whereas cells with MSI and mutant TGFBR2 were unresponsive to TGF-beta1. 20026115 2010
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis. 19293232 2009
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 PosttranslationalModification disease BEFREE Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. 17985359 2008
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 PosttranslationalModification disease BEFREE These results suggest that TGFBR2 mutations in primary colon cancers may be responsible for the increased proliferation and cdk4 expression in these tumors and provide evidence that deregulation of cdk4 is a pathogenic in vivo consequence of TGFBR2 inactivation in primary colon cancer. 16108056 2006
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation disease BEFREE Most of this risk reduction occurred in individuals with American Joint Committee on Cancer stage III tumors, although transforming growth factor-beta receptor type II mutations were associated with a significant reduction in colon cancer death in tumors with distant metastases. 11535541 2001
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation disease BEFREE Previous work has shown that loss of functional TGF-beta type II receptor (RII) due to a frameshift mutation in the 5' half of the RII gene leads to TGF-beta resistance in a highly progressed, RER+ human colon carcinoma cell line designated HCT116. 9402753 1998
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE The transforming growth factor-beta (TGF-beta) type II receptor (RII) is a colon cancer suppressor gene that is inactivated by mutation in 90% of human colon cancers arising via the microsatellite instability (MSI) pathway of carcinogenesis. 9679977 1998
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker disease BEFREE The presence of inactivating mutations in the transforming growth factor-beta (TGF-beta) type II receptor (RII) gene in the colon cancer suggests that it may behave like a tumour suppressor gene. 9664904 1998
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation disease BEFREE The RER-positive HCT 116 colon carcinoma cell line was examined for RII mutations. 7665626 1995
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 CausalMutation disease CGI