TGM2, transglutaminase 2, 7052

N. diseases: 315; N. variants: 14
Disease: Malignant neoplasm of pancreas ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease CTD_human The expression of genes contributing to pancreatic adenocarcinoma progression is influenced by the respective environment. 30108682 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease BEFREE Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer. 27792935 2016
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease BEFREE Our study supports TG2 inhibition in the pancreatic stroma as a novel strategy to block pancreatic cancer progression. 26041746 2015
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease BEFREE Resveratrol, a natural compound previously shown to inhibit neuroblastoma and pancreatic cancer in the animal models, was utilized to investigate the role of TG2 in cancer cell migration. 24725450 2014
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease BEFREE On the other hand, the induction of autophagy by the inhibition of anti-autophagic proteins, such as Bcl-2, PKCdelta, and tissue transglutaminase 2 (TG2), may lead to autophagic cell death in some apoptosis-resistant cancers (i.e., breast and pancreatic cancers), indicating that the induction of autophagy alone may also be used as a potential therapy. 20224296 2010
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 AlteredExpression disease BEFREE Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. 18413840 2008
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Biomarker disease BEFREE Tissue transglutaminase inhibits autophagy in pancreatic cancer cells. 17374730 2007