|
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TH and aromatic acid decarboxylase (AADC) mRNA and TH protein were unchanged in the midbrain in schizophrenia compared with controls.
|
28094812 |
2017 |
|
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combined schizophrenia group had higher TH and GAD67 protein levels than controls (an increase of 69.6%, P=0.01 and 19.5%, P=0.004, respectively).
|
27550734 |
2017 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to identify TH gene variants conferring risk for suicide attempt in schizophrenia while accounting for the interaction between this gene and clinical risk factors.
|
24275212 |
2014 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data suggest that the biosynthesis of catecholamine by the action of TH should be deeply involved in decreased intellectual ability in patients with schizophrenia.
|
24417771 |
2014 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
An attractive model to study processes related to neurodevelopment in schizophrenia is reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and differentiating them into different neuronal lineages. iPSCs from three schizophrenia patients and from two controls were reprogrammed from hair follicle keratinocytes, because of their accessibility and common ectodermal origin with neurons. iPSCs were differentiated into Pax6(+)/Nestin(+) neural precursors and then further differentiated into β3-Tubulin(+)/tyrosine hydroxylase(+)/DAT(+) dopaminergic neurons.
|
23732879 |
2013 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to profile the peripheral biomarkers (tyrosine hydroxylase, TH; interleukin-1beta, IL-1beta; and tumor necrosis factor-alpha, TNF-alpha) for schizophrenia and explore their relations with clinical symptoms.
|
20067853 |
2010 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The revealed differences in the susceptibility to schizophrenia depending on polymorphic allele variants in repetitive TCAT sequence in TH01 locus may be associated with the function of a regulatory element in the process of TH gene transcription.
|
19189602 |
2009 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, TH is related to various neuro-psychiatric diseases such as TH deficiency, Parkinson's disease (PD), and schizophrenia.
|
19396395 |
2009 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice born with gene knockouts of some possible schizophrenia susceptibility genes are dopamine supersensitive, and their striata reveal markedly elevated D2High states; suchgenes include dopamine-beta-hydroxylase, dopamine D4 receptors, G protein receptor kinase 6, tyrosine hydroxylase, catechol-O-methyltransferase, the trace amine-1 receptor, regulator of G protein signaling RGS9, and the RIIbeta form of cAMP-dependent protein kinase (PKA).
|
16786561 |
2006 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have suggested an association between schizophrenia and the tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) genes.
|
16741719 |
2006 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among primates, a tyrosine hydroxylase (THO1) intron STR, previously implicated in both schizophrenia and drug withdrawal delirium, exhibited frequent replacements.
|
15656986 |
2005 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the dopamine D5 receptor on chromosome 5 and the tyrosine hydroxylase gene on chromosome 11 have both been suggested as candidate genes in schizophrenia and may also be implicated in susceptibility to poor glycaemic control.
|
16459247 |
2005 |
|
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tyrosine hydroxylase (TH, a marker of dopamine-synthesizing cells), NR1 (an NMDA receptor subunit) and GluR5 (a kainate subunit) transcript levels were significantly increased in the SNc in schizophrenia.
|
14969737 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
VNTR polymorphism of tyrosine hydroxylase gene and schizophrenia in the Korean population.
|
12759555 |
2003 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.
|
11475015 |
2001 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that exon 3 of the human TH gene lacks association with schizophrenia in Japanese patients.
|
11326301 |
2001 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, an association has been reported between schizophrenia and a rare allele containing 10-repeats (A10) of a polymorphic tetranucleotide motif in the first intron of the tyrosine hydroxylase (TH) gene.
|
9564682 |
1998 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia.
|
9684913 |
1998 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
No association between the tyrosine hydroxylase microsatellite marker HUMTH01 and schizophrenia or bipolar I disorder.
|
9686421 |
1998 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that the TH gene is not likely to play a major role in the genetic predisposition to schizophrenia, mood disorders, or alcohol dependence.
|
9754624 |
1998 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus we obtained no evidence for the involvement of the two structural mutations of the TH gene in the pathogenesis of schizophrenia or PD.
|
9613851 |
1998 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia.
|
9075305 |
1997 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders.
|
8710185 |
1996 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Indeed, an association between a rare variant allele of the gene encoding TH and the occurrence of schizophrenia has been found in several populations.
|
8984738 |
1996 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.
|
8908411 |
1996 |