THBS1, thrombospondin 1, 7057

N. diseases: 480; N. variants: 10
Disease: Myocardial Infarction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE A functional single nucleotide polymorphism in the TSP-1 gene (TSP-1 A2210G) is a risk factor for familial premature myocardial infarction. 21883885 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE Our data suggests that the presence of thrombospondin-1 (rs2228262) and thrombospondin-2 (rs8089) variants need not be considered a risk for coronary artery disease or myocardial infarction among South Indians. 21762961 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease LHGDN Association of thrombospondin-1 gene polymorphisms with myocardial infarction in a Chinese Han population. 18208671 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. 16684956 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 Biomarker disease RGD To examine the role of TSP-1 in MI, we isolated rat TSP-1 complementary DNA (cDNA) and analyzed the level and distribution of the mRNA expression. 16179730 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE Recently, the TSP-1 N700S variant was proposed to be a new genetic predictor for myocardial infarction (MI) in American population, but the hypothesis was not verified in two other populations. 15140581 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction. 15007078 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 GeneticVariation disease BEFREE The THBS-1 variant allele was not associated with an altered risk of premature CAD or MI. 12482844 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.280 Biomarker disease BEFREE Similarly, hypermethylation of the thrombospondin-1 (TSP-1) gene, an angiogenesis inhibitor, was increased in MI+ cancers (27% versus 0%; P = 0.008). 9269998 1997