THBS1, thrombospondin 1, 7057

N. diseases: 480; N. variants: 10
Disease: Sjogren's Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease BEFREE We examined this possibility using a SS mouse model (thrombospondin-1 deficient (TSP1<sup>-/-</sup>)) with well-characterized ocular disease. 30314337 2018
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease BEFREE Thrombospondin-1-deficient (TSP-1<sup>-/-</sup>) mice are used as an animal model of Sjögren's Syndrome because they exhibit many of the symptoms associated with the autoimmune type of dry eye found in primary Sjögren's Syndrome. 30332778 2018
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease BEFREE Thus, our results suggest that TSP-derived peptide attenuates Sjögren's syndrome-associated dry eye and autoimmune inflammation by preventing Th17 development while promoting the induction of T<sub>regs</sub> . 28033649 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease BEFREE These results not only reveal potential immunopathogenic mechanisms underlying KCS in SS but also highlight the therapeutic potential of TSP-1. 24086667 2013
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease MGD Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. 19284971 2009
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease MGD Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. 19700744 2009
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.240 Biomarker disease MGD Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. 18787106 2008