|
Diabetes Mellitus
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Our studies demonstrate that hyperglycemia-induced TSP2 expression contributes to impaired healing in diabetes.
|
31391172 |
2019 |
|
Intervertebral disc disorder
|
0.310 |
GeneticVariation
|
group |
BEFREE |
More studies with larger sample size need to be perfected to make sure the functions of THBS2 gene polymorphisms in IDD development.
|
29480856 |
2018 |
|
Diabetes Mellitus
|
0.310 |
Biomarker
|
group |
CTD_human |
Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus.
|
23723366 |
2013 |
|
Intervertebral disc disorder
|
0.310 |
Biomarker
|
group |
CTD_human |
|
|
|
|
Diabetic Angiopathies
|
0.300 |
Biomarker
|
disease |
CTD_human |
Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
|
25381014 |
2015 |
|
Microangiopathy, Diabetic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
|
25381014 |
2015 |
|
Lumbar disc disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Cerebral Hemorrhage
|
0.200 |
Biomarker
|
phenotype |
RGD |
Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Laboratory investigation.
|
20136391 |
2010 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, TSP-2 knockdown inhibited lung cancer osteolytic metastasis in vivo.
|
31075265 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of TSP-2 and 4N1K-peptide was negatively associated with T stage, metastasis, and grade.
|
31092423 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
THBS2 expression was significantly correlated to TNM stages (p=4.1×10-5), T classification (p=0.005), lymph node metastasis (p=3×10-4) and AJCC stages (p=0), while no significant association was found in gender, age, distant metastasis or tumor size.
|
30570855 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
As miR‑203a‑3p was determined to target THBS2 to inhibit CRC progression and metastasis; thus, miR‑203a‑3p may be considered as a potential novel approach to treating CRC.
|
31545460 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data revealed that treatment of the TNBC VM phenotype cells with entinostat epigenetically led to the re‑expression of the anti‑angiogenic genes, serpin family F member 1 (SERPINF1) and thrombospondin 2 (THBS2), and to that of the tumor suppressor genes, phosphatase and tensin homolog (PTEN) and p21, and reduced VM structures.
|
31059004 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that <i>miR-1246</i> functions during cervical cancer pathogenesis and tumor formation via the THBS2/MMP/ECM signaling pathway.
|
31404330 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
THBS2 expression was significantly correlated to TNM stages (p=4.1×10-5), T classification (p=0.005), lymph node metastasis (p=3×10-4) and AJCC stages (p=0), while no significant association was found in gender, age, distant metastasis or tumor size.
|
30570855 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that TSP-2 expression is highly correlated with lung cancer tumor stage and that the TSP-2 neutralizing antibody reduces osteoclast formation in conditioned medium obtained from lung cancer cells.
|
31075265 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, a significant attenuation of tumor growth and angiogenesis was identified in vivo in the Daoy cells overexpressing TSP2 inoculated in nude mice.
|
31063715 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Fat Distribution
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
|
30664634 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of thrombospondin 2 inhibits metastasis through modulation of PI3K signaling pathway in uveal melanoma cell line M23.
|
30338785 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.
|
30031810 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The resulting diagram created with Director suggest elevated levels of COL11A1, INHBA, and THBS2 - a signature feature of metastasis [1] - and decreased levels of their targeting miRNAs define poor prognosis.
|
29157446 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis.
|
29467494 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor microarray were performed with immunohistochemical staining to examine TSP-2 expression in lung cancer patients.
|
30031810 |
2018 |