|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses identify new loci influencing intraocular pressure.
|
29617998 |
2018 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the A387P variant of the THBS4 gene may be an important determinant in the development of MI at any age.
|
15131549 |
2004 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
LHGDN |
Based on a study examining 500 myocardial infarction (MI) patients and 500 controls from the genetically isolated Newfoundland population, we previously reported that thrombospondin-4 (THBS-4) 1186G>C variant associates with MI in women.
|
16923428 |
2006 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the THBS-2 variant allele and the THBS-4 variant (387P) allele was significantly associated with a reduced risk of premature MI compared with wild-type individuals (OR=0.44, 0.24 to 0.84 and OR=0.43, 0.22 to 0.85, respectively).
|
12482844 |
2002 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Based on a study examining 500 myocardial infarction (MI) patients and 500 controls from the genetically isolated Newfoundland population, we previously reported that thrombospondin-4 (THBS-4) 1186G>C variant associates with MI in women.
|
16923428 |
2006 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
None of studied single genetic variants-F13A1 Val34Leu, THBS2 T/G 3'UTR and THBS4 Ala387Pro-and the extended CC/TT/GG haplotype of F13A1/THBS2/THBS4 genes was associated with MI in young age.
|
30972713 |
2019 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation of the putative tumor suppressor genes BCL7a (in 48% of CTCL samples), PTPRG (27%), and thrombospondin 4 (52%) was confirmed and demonstrated to be associated with transcriptional downregulation.
|
15897551 |
2005 |
|
Malignant neoplasm of stomach
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of THBS2/THBS4 polymorphisms with risk and clinicopathological features of GC in a Southeast Chinese population.
|
27160021 |
2016 |
|
Stomach Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of THBS2/THBS4 polymorphisms with risk and clinicopathological features of GC in a Southeast Chinese population.
|
27160021 |
2016 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The THBS2 3' untranslated region (UTR) polymorphism and THBS4 A387P polymorphism were not associated with overall CAD risk.
|
25976449 |
2015 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
For the THBS-4 A387P polymorphism, additional studies are required to elucidate its role in premature CAD.
|
12482844 |
2002 |
|
Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In a recent large-scale genetic association study, a single nucleotide polymorphism in the thrombospondin-4 (TSP-4) gene, resulting in a proline-for-alanine substitution at position 387, was associated with a significantly increased risk for premature atherosclerosis.
|
12952849 |
2003 |
|
Atherosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In a recent large-scale genetic association study, a single nucleotide polymorphism in the thrombospondin-4 (TSP-4) gene, resulting in a proline-for-alanine substitution at position 387, was associated with a significantly increased risk for premature atherosclerosis.
|
12952849 |
2003 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Thrombospondin-4 (TSP-4), a matricellular protein of vessel walls associated with inflammation, was investigated in terms of CVD risk using multivariable modelling with a well-characterised functional genetic polymorphism of THBS4 (rs1866389" genes_norm="7060">A387P, rs1866389) along with previously demonstrated risk-related functional genetic polymorphisms of CYBA (C242T, rs4673) and CETP (TaqIB, rs708272), and a set of blood markers.
|
22011848 |
2011 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Postinfarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels.
|
22011848 |
2011 |
|
Premature coronary artery atherosclerosis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Recently, polymorphisms in thrombospondin (THBS) genes coding for THBS-1 (N700S), THBS-2 (T>G substitution in 3'-untranslated region), and THBS-4 (A387P) genes were proposed to modulate the risk of premature coronary artery disease (CAD) or myocardial infarction (MI).
|
12482844 |
2002 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growth by TGF-β despite the inhibition of cancer cell proliferation.
|
28481870 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
THBS4 may act as a tumour suppressor gene, demonstrated by its suppression of tumour colony formation in vitro.
|
20846368 |
2010 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Up-regulation of thrombospondin-4 (TSP4) or voltage-gated calcium channel subunit α<sub>2</sub>δ<sub>1</sub> (Ca<sub>v</sub>α<sub>2</sub>δ<sub>1</sub>) proteins in the spinal cord contributes to neuropathic pain development through an unidentified mechanism.
|
30194282 |
2018 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Controlling TSP4 mediated intracellular Ca<sup>2+</sup> signaling in peripheral sensory neurons may be a target for analgesic drug development for neuropathic pain.
|
28232180 |
2017 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
These results provide biochemical evidence that supports a specific role of TSP-4 among the TSPs in mediating the binding to neuronal α<sub>2</sub>δ-1 and suggest that gabapentin does not directly target TSP/α<sub>2</sub>δ-1 interaction to alleviate neuropathic pain.
|
31700036 |
2019 |