|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses identify new loci influencing intraocular pressure.
|
29617998 |
2018 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
None of studied single genetic variants-F13A1 Val34Leu, THBS2 T/G 3'UTR and THBS4 Ala387Pro-and the extended CC/TT/GG haplotype of F13A1/THBS2/THBS4 genes was associated with MI in young age.
|
30972713 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer.
|
31703077 |
2019 |
|
Myocardial Infarction
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension.
|
29729633 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growth by TGF-β despite the inhibition of cancer cell proliferation.
|
28481870 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
While THBS4 is often overexpressed in HCC it has also been shown to inhibit tumor growth by mediating cell-to-cell and cell-to-matrix interactions.
|
28177895 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
THBS4 mRNA expression in human stomach was associated with tumor size (P = 0.002) and tumor-node-metastasis (TNM) (P = 0.010), and THBS2 mRNA expression was associated with the TNM (P = 0.010).
|
27160021 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
THBS4 may act as a tumour suppressor gene, demonstrated by its suppression of tumour colony formation in vitro.
|
20846368 |
2010 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
LHGDN |
Based on a study examining 500 myocardial infarction (MI) patients and 500 controls from the genetically isolated Newfoundland population, we previously reported that thrombospondin-4 (THBS-4) 1186G>C variant associates with MI in women.
|
16923428 |
2006 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Based on a study examining 500 myocardial infarction (MI) patients and 500 controls from the genetically isolated Newfoundland population, we previously reported that thrombospondin-4 (THBS-4) 1186G>C variant associates with MI in women.
|
16923428 |
2006 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation of the putative tumor suppressor genes BCL7a (in 48% of CTCL samples), PTPRG (27%), and thrombospondin 4 (52%) was confirmed and demonstrated to be associated with transcriptional downregulation.
|
15897551 |
2005 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the A387P variant of the THBS4 gene may be an important determinant in the development of MI at any age.
|
15131549 |
2004 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the THBS-2 variant allele and the THBS-4 variant (387P) allele was significantly associated with a reduced risk of premature MI compared with wild-type individuals (OR=0.44, 0.24 to 0.84 and OR=0.43, 0.22 to 0.85, respectively).
|
12482844 |
2002 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
These results provide biochemical evidence that supports a specific role of TSP-4 among the TSPs in mediating the binding to neuronal α<sub>2</sub>δ-1 and suggest that gabapentin does not directly target TSP/α<sub>2</sub>δ-1 interaction to alleviate neuropathic pain.
|
31700036 |
2019 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Up-regulation of thrombospondin-4 (TSP4) or voltage-gated calcium channel subunit α<sub>2</sub>δ<sub>1</sub> (Ca<sub>v</sub>α<sub>2</sub>δ<sub>1</sub>) proteins in the spinal cord contributes to neuropathic pain development through an unidentified mechanism.
|
30194282 |
2018 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Nerve injury induces concurrent up-regulation of the voltage-gated calcium channel subunit Ca<sub>v</sub> α<sub>2</sub> δ<sub>1</sub> and the extracellular matrix protein thrombospondin-4 (TSP4) in dorsal root ganglia and dorsal spinal cord, leading to the development of a neuropathic pain state.
|
29338087 |
2018 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Controlling TSP4 mediated intracellular Ca<sup>2+</sup> signaling in peripheral sensory neurons may be a target for analgesic drug development for neuropathic pain.
|
28232180 |
2017 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Development of TSP4 antagonists has the therapeutic potential for target-specific neuropathic pain management.
|
22745497 |
2012 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
THBS4 expression in cancer-associated fibroblasts (CAFs), normal-associated fibroblasts (NFs) and gastric cancer cell lines was examined by western blotting.
|
31703077 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to study THBS4 expression in hepatocellular carcinoma (HCC) and determine if it was a prognostic marker for this malignancy.
|
30802535 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Further, the bioinformatics analysis of the cancer genome atlas dataset suggested that there may be a positive correlation between THBS4 and KLF9 expression.
|
30746617 |
2019 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The analysis of Gene Expression Omnibus (GEO) dataset (GSE26253) suggested that THBS4 was up-regulated in recurrent GC patients and was positively correlated with the increase in pathological stage and poor prognosis in GC.
|
30746617 |
2019 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
THBS4 is expressed on CAFs in the gastric cancer microenvironment.
|
31703077 |
2019 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The analysis of Gene Expression Omnibus (GEO) dataset (GSE26253) suggested that THBS4 was up-regulated in recurrent GC patients and was positively correlated with the increase in pathological stage and poor prognosis in GC.
|
30746617 |
2019 |