In conclusion, DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage, which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1nephritis.
Thy-1 nephritis (Thy-1 N), namely, anti-Thy-1 or anti-thymocyte serum (ATS) induced nephritis (ATSN), is a typical model of human mesangioproliferative glomerulonephritis.
Analysis of glomerular FN mRNA demonstrated inclusion of both ED regions in rats with anti-Thy1nephritis or chronic serum sickness and in mice with anti-GBM glomerulonephritis.