As a conclusion, a decrease in CDH1, CDH13, and TIMP3 expression levels with an increase in CD44 can be used as an indicator for invasion in both ER-positive and -negative breast tumors.
Expression of TIMP-3 gene by construction of a eukaryotic cell expression vector and its role in reduction of metastasis in a human breast cancer cell line.
On the basis of these expression data in breast tumors, together with its high degree of structural homology with chicken inhibitor of metalloproteinase 3, a possible role for human TIMP-3 in the regulation of connective tissue turnover and remodeling is proposed.