NKX2-1, NK2 homeobox 1, 7080

N. diseases: 319; N. variants: 20
Disease: Carcinoma, Small Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 Biomarker disease BEFREE Thyroid transcription factor 1 (TTF-1) was also included, given its positivity in a subset of small cell carcinomas. 31040050 2019
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 Biomarker disease BEFREE We examined the expression of p16, CD56, synaptophysin (SYP), chromogranin A and thyroid transcription factor-1 (TTF1) in a series of pulmonary and extrapulmonary small cell carcinomas, pulmonary carcinoids and non-small cell lung carcinomas, and compared diagnostic performance of these markers in the diagnosis of SCLC. 29566943 2018
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 AlteredExpression disease BEFREE The TTF-1 expression of pulmonary SCC illustrating diffuse and strong positivity in tumor cell nuclei was significantly higher than that of the cervical SCC (P = .003). 30045295 2018
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 AlteredExpression disease BEFREE However, among lung neuroendocrine tumors, small-cell carcinomas (small-cell lung cancers (SCLCs)), most of which are generated from the central airway, also frequently express TTF1 at high levels. 23358112 2013
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 Biomarker disease BEFREE Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. 17727473 2007
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 AlteredExpression disease BEFREE Immunohistochemically, the small cell carcinoma expressed TTF-1, pancytokeratin, CD56, synaptophysin, and S100 protein, while blastemal cells expressed vimentin, desmin, smooth muscle actin, CD56, and S100 protein. 17046168 2006
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 AlteredExpression disease BEFREE Patients with TTF-1 expression had poorer survivals in small cell carcinoma. 16862075 2006
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.080 AlteredExpression disease BEFREE Results obtained using RNase protection assay confirmed that TTF-1 was expressed only in a subset of non-small cell carcinomas. 8814700 1996