|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Tendency of higher Sec62-IRS-scores were found for tumors with higher Clark levels and a tumor size >5 cm<sup>2</sup>.
|
30675236 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We analyzed SEC62 and SOX2 expression in tissue specimens from 65 HNSCC patients and 29 patients with cervical cancer of unknown primary (CUP); a higher SEC62 and lower SOX2 expression was observed in the lymph node metastases from HNSCC patients compared with the respective primary tumor.
|
28002801 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, Sec62 is not only a predictive marker for this type of tumor, but also an interesting therapeutic target.
|
24304694 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Correlation analyses revealed significantly higher Sec62 levels in tumors with lymph node metastases compared with nonmetastatic tumors, as well as in poorly compared with moderately differentiated tumors.
|
22197383 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, the SEC62 gene may indeed be considered as a target gene in the therapy of various tumors.
|
20669223 |
2011 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
RT-PCR analyses revealed that hTR and TP I mRNA were constitutively expressed both in tumor and in normal tissues.
|
9808519 |
1998 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Sec62/Ki67 dual-staining immunocytochemistry is a promising cytological tool for interpreting high-grade squamous lesions in cytological specimens and for assessing the risk of progression to cancer.
|
30498965 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Sec62/Ki67 dual-staining immunocytochemistry is a promising cytological tool for interpreting high-grade squamous lesions in cytological specimens and for assessing the risk of progression to cancer.
|
30498965 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Expression levels of Sec62 and vimentin were analyzed in liquid based cytology specimens from 107 women with varying grades of cervical dysplasia ranging from normal cases to cancer by immunofluorescence cytology.
|
27553742 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Expression levels of Sec62 and vimentin were analyzed in liquid based cytology specimens from 107 women with varying grades of cervical dysplasia ranging from normal cases to cancer by immunofluorescence cytology.
|
27553742 |
2016 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
|
23764425 |
2013 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
|
23764425 |
2013 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
On the basis of these promising results, we examined the role of Sec62 in cancer cell biology in vitro.
|
22197383 |
2012 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
On the basis of these promising results, we examined the role of Sec62 in cancer cell biology in vitro.
|
22197383 |
2012 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer.
|
30747329 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In the previous studies, we demonstrated that Sec62 is essential for tumor cell migration, epithelial-to-mesenchymal transition, and intracellular stress tolerance.
|
30498965 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Sec62 is a potentially prognostic factor for early recurrence in postoperative HCC patients and promotes HCC metastasis through integrinα/CAV1 signalling.
|
31822656 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
SEC62 expression correlated with distant and lymph node metastasis and poor outcome in different cancer entities.
|
30747329 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
When proceeding from the N1 to the N3 stage, SEC62 expression in the lymph node metastases showed an increase and SOX2 expression showed a decrease.
|
28002801 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Correlation analyses revealed significantly higher Sec62 levels in tumors with lymph node metastases compared with nonmetastatic tumors, as well as in poorly compared with moderately differentiated tumors.
|
22197383 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sec62 is involved in endoplasmic reticulum stress tolerance and cell migration, and has been identified as a novel prognostic marker for non-small cell lung cancer as well as head and neck squamous cell carcinoma.
|
30675236 |
2019 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
All 56 (n = 56, 100%) cases of cervical intraepithelial neoplasia grade 3 and cervical cancer (CIN3+ lesions) were positive for Sec62/Ki67 staining, while low-grade lesions and normal cells were negative.
|
30498965 |
2019 |
|
Cervical dysplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An increase in Sec62 expression correlated with an increase in cervical dysplasia severity in liquid-based cytology specimens.
|
30498965 |
2019 |
|
Cervical Intraepithelial Neoplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An increase in Sec62 expression correlated with an increase in cervical dysplasia severity in liquid-based cytology specimens.
|
30498965 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
All 56 (n = 56, 100%) cases of cervical intraepithelial neoplasia grade 3 and cervical cancer (CIN3+ lesions) were positive for Sec62/Ki67 staining, while low-grade lesions and normal cells were negative.
|
30498965 |
2019 |