|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The AA genotype of rs5743557 was associated with reduced TB risk (P=0.006) and the AA/GA genotypes of <i>TLR1</i> rs5743604 were associated with increased TB risk (P=0.017) when the LTBI group was compared with the TB group.
|
30963003 |
2019 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study mainly investigated the relationship between polymorphisms of TLR1 and tuberculosis (TB) susceptibility in the two Chinese populations.
|
29454979 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rs5743565 and rs5743557 in the TLR1 gene may contribute to decreased risk for tuberculosis susceptibility in a Western Chinese population.
|
29416723 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association analyses yielded a significant result for the TLR1 variant rs3923647, conferring strong protection against TB (Odds ratio [OR] 0.21, CI confidence interval [CI] 0.05-0.6, Pnominal 1 x 10-3) when applying a recessive model of inheritance.
|
27214039 |
2016 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cohort analysis associated the TLR1-248N SNP (RS4833095) with TB protection.
|
25857934 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification.
|
26559095 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An increased risk of TB was found for individuals with the TLR2 rs3804100 CC and the TLR9 rs352139 GA and GG genotypes, while decreased risk was identified for those with the AG genotype of TLR1 rs4833095.
|
26430737 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To conclude, TLR1 rs5743618 G allele was found associated to susceptibility to TB in Han Chinese pediatric population.
|
25544311 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR1 G1805T is associated with increased TB in Africans and American Hispanics.
|
23691034 |
2013 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data gain new insights in the role of TLR1 in M. tuberculosis defense and provide the first evidence that TLR1 variants are associated with susceptibility to TB in a low-incidence country.
|
21642391 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common nonsynonymous polymorphisms in TLR6-TLR1-TLR10 also were significantly associated with TB disease in certain ethnic groups.
|
18091991 |
2007 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Half-life studies using blood from patients with pulmonary tuberculosis and THP1 cells exposed to Myobacterium tuberculosis in vitro showed p38 MAPK-independent stabilization of mRNAs encoding hsTLR1 and TLR1.
|
16493059 |
2006 |