Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins.
|
29457581 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Lipoteichoic acid (LTA) and lipoproteins are representative TLR2 ligands that play important roles in bacterial infection and in host inflammatory responses.
|
30176521 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we focused on the pathways regulating immune responses in murine macrophages and modeled post viral-bacterial infections through pretreatment of bone marrow-derived macrophages (BMDMs) with a toll-like receptor (TLR) 7/8 ligand (R848) and subsequent challenge with TLR2/4 agonists to mimic bacterial infection.
|
29515583 |
2018 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results confirmed pro-inflammatory function of extracellular Hsp70, and suggest its possible implication in COPD exacerbations caused by bacterial infection through desensitization or inappropriate activation of TLR2 and TLR4 receptors.
|
29067554 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
There was also a moderate positive correlation between the expression Myd88-Tnfrsf11 and Tlr2-Myd88, suggesting the relevance of Tlr2-Myd88 in bone loss due to bacterial infection.
|
29995146 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore examined a bacterial infection scenario involving co-stimulation of TLR4 and TLR2.
|
28380352 |
2017 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This early response to viral capsids required the cell surface-expressed PRR TLR2 and allowed for improved clearance of subsequent bacterial infection that commonly complicates respiratory viral infections.
|
29138299 |
2017 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus.
|
28858870 |
2017 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML and bacterial infection in comparison with group with separate fungal infection (ΔCt TLR2 1.15 ± 1.06 vs 0.66 ± 0.51 and ΔCt TLR4 0.45 ± 0.38 vs 0.21 ± 0.19).
|
25412934 |
2014 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Impaired airway innate immunity (e.g., suppressed Toll-like receptor 2 [TLR2] signaling) has been reported in allergic lungs with bacterial infection.
|
21892915 |
2011 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings may offer a deliverable approach to attenuate bacterial infections in airways of asthma or chronic obstructive pulmonary disease patients with impaired TLR2 function.
|
21239529 |
2011 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Increased mast cell IL-6 production in response to combined TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation-dependent conditions.
|
20861644 |
2011 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study indicated that TLR2 activation by infectious bacterial PGN played an important role in breast cancer cell invasiveness and illustrated a new link between infectious bacteria and the cancer cells, suggesting the importance of antibiotic therapy to treat cancer with bacterial infection.
|
20520770 |
2010 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that during bacterial infection in vivo, newborns selectively and coordinately amplify the TLR2-MyD88 pathway in G+ bacterial infection and the TLR4/MD2/MyD88 pathway in G- bacterial infection, suggesting key roles for innate immune pathway in neonatal responses to bacterial infection.
|
20805788 |
2010 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling in response to bacterial infection.
|
19592497 |
2009 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our study thus provides novel insights into the regulation of TLR2 expression in mixed bacterial infections.
|
18664270 |
2008 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results have indicated that there is a strong significant relationship between susceptibility to recurrent bacterial infections and Arg753Gln polymorphism of the TLR-2 gene.
|
17554618 |
2007 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Arg753Gln polymorphism of the human toll-like receptor-2 gene in children with recurrent febrile infections.
|
17554618 |
2007 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TLR2 and TLR4 expression during bacterial infections.
|
17100621 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection.
|
16818794 |
2006 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients.
|
16487238 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection.
|
16818794 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
TLR2 and TLR4 expression during bacterial infections.
|
17100621 |
2006 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Thus, our study provides new insights into the role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections and may lead to new therapeutic strategies for modulating host defense and inflammatory response.
|
16754688 |
2006 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, our study provides new insights into the role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections and may lead to new therapeutic strategies for modulating host defense and inflammatory response.
|
16754688 |
2006 |