|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis revealed a novel finding that the heterogeneous "GA" genotype of the TLR2 rs5743708 and "AG" genotype of the TLR4 rs4986790 may be associated with increased susceptibility to atopic dermatitis in Caucasians.
|
30273064 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Keratinocytes from both healthy and AD skin expressed similar levels of TLR2.
|
29672867 |
2018 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of Toll-Like Cell Receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) Polymorphisms with Indicators of General and Local Immunity in Patients with Atopic Dermatitis.
|
28593178 |
2017 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Turkish children.
|
28443596 |
2017 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant correlations between TLR2(+) (but not TLR4(+)) PB monocytes and the objective Scoring Atopic Dermatitis index (r = 0.604, p < 0.001), serum levels of IL-17a and TLR2(+) PB monocytes (r = 0.416, p = 0.027), and IL-4 and TLR2(+) PB monocytes (r = -0.307, p = 0.014) were observed during AD exacerbation.
|
26534745 |
2016 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Peripheral blood monocytes from patients with severe extrinsic AD or healthy control patients were treated with the TLR2 agonist Pam3CSK4.
|
25912722 |
2015 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the effect of TLR2 ligands on the development of TH2-mediated AD inflammation remains unclear.
|
24698321 |
2014 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair.
|
23223142 |
2013 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Distinct number of Tregs and various distribution of TLR2 and TLR4 expression on PBMC in AD patients suggest their contribution in the pathogenesis of AD.
|
22686584 |
2012 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate intrinsic TLR-2 expression and cytokine secretion upon TLR-2 stimulation with peptidoglycan (PGN), lipoteichoic acid (LTA) and N-palmitoyl-S-[2,3-bis(palmitoyl)-(2RS)-propyl]-(R)cysteinyl-alanyl-glycine (Pam3Cys) in keratinocytes from patients with AD compared to healthy controls.
|
21447101 |
2011 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, our findings show a functional role of IL-31 in HPKs and provide a new link between TLR-2 ligands and IL-31 which might be dysregulated in AD.
|
21261663 |
2011 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSION Children with AD may have a distinct genotype and the TLR-2 R753Q SNP was prevalent in a subset of patients with AD characterized by a more severe clinical picture.
|
22032785 |
2011 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for TLR2–16934A>T polymorphism was performed in 130 consecutive adult ambulatory patients with AD.
|
21134221 |
2011 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphism.
|
19849713 |
2010 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We could clearly show that macrophages from patients with AD expressed significantly less TLR-2, whereas the expression pattern of TLR-1 and TLR-6 were not altered.
|
19392987 |
2009 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a subgroup of patients suffering from severe AD (SCORAD >50), a significantly increased representation of the A-allele in position -16934 of the tlr2 gene was present (P = 0.004).
|
19627277 |
2009 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR-2 may be essential in the pathogenesis and maintenance of AD and may be involved in the enhanced susceptibility to skin infections with S. aureus and in a higher inflammatory response in patients with AD carrying the TLR-2 polymorphism.
|
18445187 |
2008 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In contrast, LTA decreased TLR-2 expression among nonatopic individuals and patients with AD with the TLR-2 wild-type gene.
|
18234309 |
2008 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, LTA decreased TLR-2 expression among nonatopic individuals and patients with AD with the TLR-2 wild-type gene.
|
18234309 |
2008 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
TLR-2 may be essential in the pathogenesis and maintenance of AD and may be involved in the enhanced susceptibility to skin infections with S. aureus and in a higher inflammatory response in patients with AD carrying the TLR-2 polymorphism.
|
18445187 |
2008 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Monocytes, particularly the proinflammatory monocytes, from patients with AD are functionally defective in their capacity to produce proinflammatory cytokines on TLR2 stimuli in part because of the high levels of their FcvarepsilonRI expression.
|
17531301 |
2007 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype.
|
15007364 |
2004 |